An ESCRT into the endosome

被引:29
作者
Conibear, E [1 ]
机构
[1] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
关键词
D O I
10.1016/S1097-2765(02)00601-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multivesicular endosomes sort ubiquitinated membrane proteins for degradation by incorporating them into inwardly budding vesicles. The recent identification of two new oligomeric components of the sorting machinery gives us a detailed view of the complex protein-protein interactions driving this process.
引用
收藏
页码:215 / 216
页数:2
相关论文
共 10 条
[1]   The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways [J].
Amerik, AY ;
Nowak, J ;
Swaminathan, S ;
Hochstrasser, M .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (10) :3365-3380
[2]   Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body [J].
Babst, M ;
Katzmann, DJ ;
Snyder, WB ;
Wendland, B ;
Emr, SD .
DEVELOPMENTAL CELL, 2002, 3 (02) :283-289
[3]   ESCRT-III: An endosome-associated heterooligomeric protein complex required for MVB sorting [J].
Babst, M ;
Katzmann, DJ ;
Estepa-Sabal, EJ ;
Meerloo, T ;
Emr, SD .
DEVELOPMENTAL CELL, 2002, 3 (02) :271-282
[4]   Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking [J].
Babst, M ;
Odorizzi, G ;
Estepa, EJ ;
Emr, SD .
TRAFFIC, 2000, 1 (03) :248-258
[5]   The Vps27p-Hse1p complex binds ubiquitin and mediates endosomal protein sorting [J].
Bilodeau, PS ;
Urbanowski, JL ;
Winistorfer, SC ;
Piper, RC .
NATURE CELL BIOLOGY, 2002, 4 (07) :534-539
[6]   Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates [J].
Bishop, N ;
Horman, A ;
Woodman, P .
JOURNAL OF CELL BIOLOGY, 2002, 157 (01) :91-101
[7]   Tsg101: HIV-1's ticket to ride [J].
Carter, CA .
TRENDS IN MICROBIOLOGY, 2002, 10 (05) :203-205
[8]   A new ticket for entry into budding vesicles - Ubiquitin [J].
Hicke, L .
CELL, 2001, 106 (05) :527-530
[9]   Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I [J].
Katzmann, DJ ;
Babst, M ;
Emr, SD .
CELL, 2001, 106 (02) :145-155
[10]   A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins [J].
Polo, S ;
Sigismund, S ;
Faretta, M ;
Guidi, M ;
Capua, MR ;
Bossi, G ;
Chen, H ;
De Camilli, P ;
Di Fiore, PP .
NATURE, 2002, 416 (6879) :451-455