MicroRNA-148a: A potential therapeutic target for cancer

被引:22
作者
Chen, Zhaolin [1 ]
Ma, Taotao [1 ]
Huang, Cheng [1 ]
Zhang, Lei [1 ]
Xu, Tao [1 ]
Hu, Tingting [1 ]
Li, Jun [1 ]
机构
[1] Anhui Med Univ, Sch Pharm, Anhui Key Lab Bioact Nat Prod, Inst Liver Dis, Hefei 230032, Peoples R China
关键词
miR-148a; DNMT1;
D O I
10.1016/j.gene.2013.09.067
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学];
摘要
MicroRNA-148a (miR-148a) which suppresses tumor growth by directly decreasing DNMT1 expression has been demonstrated as an important role for cancer therapy. The mechanisms for miR-148a in cancer will become potential future researches. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:456 / 457
页数:2
相关论文
共 7 条
[1]
Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility [J].
Aprelikova, O. ;
Palla, J. ;
Hibler, B. ;
Yu, X. ;
Greer, Y. E. ;
Yi, M. ;
Stephens, R. ;
Maxwell, G. L. ;
Jazaeri, A. ;
Risinger, J. I. ;
Rubin, J. S. ;
Niederhuber, J. .
ONCOGENE, 2013, 32 (27) :3246-3253
[2]
MicroRNA-Dependent Regulation of DNA Methyltransferase-1 and Tumor Suppressor Gene Expression by Interleukin-6 in Human Malignant Cholangiocytes [J].
Braconi, Chiara ;
Huang, Nianyuan ;
Patel, Tushar .
HEPATOLOGY, 2010, 51 (03) :881-890
[3]
miR-148a Plays a Pivotal Role in the Liver by Promoting the Hepatospecific Phenotype and Suppressing the Invasiveness of Transformed Cells [J].
Gailhouste, Luc ;
Gomez-Santos, Laura ;
Hagiwara, Keitaro ;
Hatada, Izuho ;
Kitagawa, Noriyuki ;
Kawaharada, Kazushi ;
Thirion, Muriel ;
Kosaka, Nobuyoshi ;
Takahashi, Ryou-u ;
Shibata, Tatsuhiro ;
Miyajima, Atsushi ;
Ochiya, Takahiro .
HEPATOLOGY, 2013, 58 (03) :1153-1165
[4]
Biochemistry and biology of mammalian DNA methyltransferases [J].
Hermann, A ;
Gowher, H ;
Jeltsch, A .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (19-20) :2571-2587
[5]
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1 [J].
Xu, Qing ;
Jiang, Yue ;
Yin, Yu ;
Li, Qi ;
He, Jun ;
Jing, Yi ;
Qi, Yan-Ting ;
Xu, Qian ;
Li, Wei ;
Lu, Bo ;
Peiper, Stephen S. ;
Jiang, Bing-Hua ;
Liu, Ling-Zhi .
JOURNAL OF MOLECULAR CELL BIOLOGY, 2013, 5 (01) :3-13
[6]
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer [J].
Zhu, Akao ;
Xia, Jiazeng ;
Zuo, Junbo ;
Jin, Shimao ;
Zhou, Hong ;
Yao, Lubin ;
Huang, Hongyu ;
Han, Zhijun .
MEDICAL ONCOLOGY, 2012, 29 (04) :2701-2709
[7]
MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer [J].
Zuo, Junbo ;
Xia, Jiazeng ;
Ju, Feng ;
Yan, Jiang ;
Zhu, Akao ;
Jin, Shimao ;
Shan, Ting ;
Zhou, Hong .
MOLECULES AND CELLS, 2013, 35 (04) :313-319