Tumor microenvironment: regulatory cells and immunosuppressive cytokines

被引：12

作者：

Bruchard, Melanie ^{[1
]}

Ghiringhelli, Francois ^{[1
,2
]}

机构：

[1] Fac Med & Pharm Dijon, INSERM, Dijon, France

[2] Ctr Georges Francois Leclerc, Dijon, France

来源：

M S-MEDECINE SCIENCES | 2014年 / 30卷 / 04期

关键词：

T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; GROWTH-FACTOR; CANCER; INTERLEUKIN-6; INFLAMMATION; TH17; SUBPOPULATIONS; MECHANISMS;

D O I：

10.1051/medsci/20143004018

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Immunosuppression is a mechanism developed by cancer cells to help them escape the immune system. Immunosuppression involves expansion of various cell types and production of a variety of cytokines. In this review, we explore the duality of three cancer induced cell populations, regulatory T lymphocytes, Th17 lymphocytes and MDSC, and also the pleiotropic effects of several cytokines induced during cancer development.

引用

页码：429 / 435

页数：7

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