VIRAL LOAD IN INFANTS HOSPITALIZED FOR RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS CORRELATES WITH RECURRENT WHEEZING AT THIRTY-SIX-MONTH FOLLOW-UP

被引：41

作者：

Nenna, Raffaella ^{[1
]}

Ferrara, Marianna ^{[1
]}

Nicolai, Ambra ^{[2
]}

Pierangeli, Alessandra ^{[2
]}

Scagnolari, Carolina ^{[1
]}

Papoff, Paola ^{[2
]}

Antonelli, Guido ^{[1
]}

Moretti, Corrado

Midulla, Fabio ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Paediat, Viale Regina Elena 324, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Dept Mol Med, Virol Lab, I-00161 Rome, Italy

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2015年 / 34卷 / 10期

关键词：

respiratory syncytial virus; bronchiolitis; viral load; interferon-lambda; ASTHMA;

D O I：

10.1097/INF.0000000000000825

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-lambda 1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-lambda 2/3 levels were found in children with recurrent wheezing at 36-month follow-up.

引用

页码：1131 / 1132

页数：2

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