N-acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis

被引：73

作者：

Hein, DW ^{[1
]}

机构：

[1] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA

来源：

TOXICOLOGY LETTERS | 2000年 / 112卷

关键词：

N-acetyltransferase; acetylation polymorphisms; molecular epidemiology; colorectal cancer; breast cancer;

D O I：

10.1016/S0378-4274(99)00226-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

N-Acetyltransferases (EC 2.3.1.5) are important in both the activation and deactivation of aromatic and heterocyclic amine carcinogens. Two N-acetyltransferase isozymes (NAT1 and NAT2) encoded by NAT1 and NAT2, respectively, have been identified. Both NAT1 and NAT2 exhibit genetic polymorphisms, and recent investigations have increased our understanding of the relationship between genotype and phenotype. Several studies have shown a role for NAT1 and NAT2 acetylation polymorphisms in cancer risk in human populations, but the findings have been inconsistent. These findings may relate to variability in carcinogen exposures and to differences in acetylator genotype/phenotype determinations. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：349 / 356

页数：8

共 51 条

[21] Rodent models of the human acetylation polymorphism: Comparisons of recombinant acetyltransferases [J].

Hein, DW ;

Doll, MA ;

Fretland, AJ ;

Gray, K ;

Deitz, AC ;

Feng, Y ;

Jiang, W ;

Rustan, TD ;

Satran, SL ;

Wilkie, TR .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1997, 376 (1-2) :101-106

[22] METABOLIC-ACTIVATION OF AROMATIC AND HETEROCYCLIC N-HYDROXYARYLAMINES BY WILD-TYPE AND MUTANT RECOMBINANT HUMAN NAT1 AND NAT2 ACETYLTRANSFERASES [J].

HEIN, DW ;

RUSTAN, TD ;

FERGUSON, RJ ;

DOLL, MA ;

GRAY, K .

ARCHIVES OF TOXICOLOGY, 1994, 68 (02) :129-133

[23] ACETYLATOR GENOTYPE AND ARYLAMINE-INDUCED CARCINOGENESIS [J].

HEIN, DW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 948 (01) :37-66

[24]

Henning S, 1999, PHARMACOGENETICS, V9, P103

[25] ENZYME-KINETIC PROPERTIES OF HUMAN RECOMBINANT ARYLAMINE N-ACETYLTRANSFERASE-2 ALLOTYPIC VARIANTS EXPRESSED IN ESCHERICHIA-COLI [J].

HICKMAN, D ;

PALAMANDA, JR ;

UNADKAT, JD ;

SIM, E .

BIOCHEMICAL PHARMACOLOGY, 1995, 50 (05) :697-703

[26] N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions [J].

Hubbard, AL ;

Harrison, DJ ;

Moyes, C ;

Wyllie, AH ;

Cunningham, C ;

Mannion, E ;

Smith, CAD .

GUT, 1997, 41 (02) :229-234

[27] Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe [J].

Hughes, NC ;

Janezic, SA ;

McQueen, KL ;

Jewett, MAS ;

Castranio, T ;

Bell, DA ;

Grant, DM .

PHARMACOGENETICS, 1998, 8 (01) :55-66

[28]

ILETT KF, 1987, CANCER RES, V47, P1466

[29]

Kampman E, 1999, CANCER EPIDEM BIOMAR, V8, P15

[30]

LADERO JM, 1991, CANCER RES, V51, P2098

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