Synthesis and profile of SCH351591, a novel PDE4 inhibitor

被引：22

作者：

Billah, M

Cooper, N

Cuss, F

Davenport, RJ

Dyke, HJ

Egan, R

Ganguly, A

Gowers, L

Hannah, DR

Haughan, AF

Kendall, HJ

Lowe, C

Minnicozzi, M

Montana, JG

Naylor, R

Oxford, J

Peake, JC

Piwinski, JJ

Runcie, KA

Sabin, V

Sharpe, A

Shih, NY

Warneck, JBH

机构：

[1] Celltech Grp Plc, Cambridge CB1 6GS, England

[2] Univ Bradford, Dept Pharmacol, Bradford BD7 1DP, W Yorkshire, England

[3] Schering Plough Corp, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00225-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1621 / 1623

页数：3

共 7 条

[1] 8-methoxyquinolines as PDE4 inhibitors
Billah, M
Buckley, GM
Cooper, N
Dyke, HJ
Egan, R
Ganguly, A
Gowers, L
Haughan, AF
Kendall, HJ
Lowe, C
Minnicozzi, M
Montana, JG
Oxford, J
Peake, JC
Picken, CL
Piwinski, JJ
Naylor, R
Sabin, V
Shih, NY
Warneck, JBH
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (12) : 1617 - 1619
[2] EMESIS INDUCED BY CISPLATIN IN THE FERRET AS A MODEL FOR THE DETECTION OF ANTIEMETIC DRUGS
COSTALL, B
DOMENEY, AM
NAYLOR, RJ
TATTERSALL, FD
[J]. NEUROPHARMACOLOGY, 1987, 26 (09) : 1321 - 1326
[3] Phosphodiesterase 4 inhibitors for the treatment of asthma
Karlsson, JA
Aldous, D
[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (09) : 989 - 1003
[4] INHIBITORY EFFECT OF THE TRFK-5 ANTI-IL-5 ANTIBODY IN A GUINEA-PIG MODEL OF ASTHMA
MAUSER, PJ
PITMAN, A
WITT, A
FERNANDEZ, X
ZURCHER, J
KUNG, T
JONES, H
WATNICK, AS
EGAN, RW
KREUTNER, W
ADAMS, GK
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (06): : 1623 - 1627
[5] EFFECTS OF AN ANTIBODY TO INTERLEUKIN-5 IN A MONKEY MODEL OF ASTHMA
MAUSER, PJ
PITMAN, AM
FERNANDEZ, X
FORAN, SK
ADAMS, GK
KREUTNER, W
EGAN, RW
CHAPMAN, RW
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (02) : 467 - 472
[6] STEREOSPECIFIC BINDING OF THE ANTIDEPRESSANT ROLIPRAM TO BRAIN PROTEIN STRUCTURES
SCHNEIDER, HH
SCHMIECHEN, R
BREZINSKI, M
SEIDLER, J
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 127 (1-2) : 105 - 115
[7] Thompson W J, 1979, Adv Cyclic Nucleotide Res, V10, P69

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