Stem Cells Therapy for Spinal Cord Injury

被引：117

作者：

Gazdic, Marina ^{[1
]}

Volarevic, Vladislav ^{[2
]}

Harrell, C. Randall ^{[3
]}

Fellabaum, Crissy ^{[3
]}

Jovicic, Nemanja ^{[4
]}

Arsenijevic, Nebojsa ^{[2
]}

Stojkovic, Miodrag ^{[1
,5
]}

机构：

[1] Univ Kragujevac, Dept Genet, Fac Med Sci, Kragujevac 34000, Serbia

[2] Univ Kragujevac, Fac Med Sci, Dept Microbiol & Immunol, Ctr Mol Med & Stem Cell Res, Kragujevac 34000, Serbia

[3] Regenerat Proc Plant LLC, 34176 US Highway 19 N, Palm Harbor, FL 34684 USA

[4] Univ Kragujevac, Dept Histol & Embryol, Fac Med Sci, Kragujevac 34000, Serbia

[5] Spebo Med, 16 Norvezanska, Leskovac 16000, Serbia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 04期

关键词：

spinal cord injury; stem cells; embryonic stem cells; induced pluripotent stem cells; ependymal stem/progenitor cells; METHYLPREDNISOLONE SODIUM SUCCINATE; PROGENITOR CELLS; OLIGODENDROCYTE PROGENITORS; STEM/PROGENITOR CELLS; FUNCTIONAL RECOVERY; NEURAL PRECURSORS; GLIAL-CELLS; DIFFERENTIATION; TRANSPLANTATION; EXPRESSION;

D O I：

10.3390/ijms19041039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously healthy young adults. Current therapeutic strategies for SCI includes surgical decompression and pharmacotherapy, however, there is still no gold standard for the treatment of this devastating condition. Inefficiency and adverse effects of standard therapy indicate that novel therapeutic strategies are required. Because of their neuroregenerative and neuroprotective properties, stem cells are a promising tool for the treatment of SCI. Herein, we summarize and discuss the promising therapeutic potential of human embryonic stem cells (hESC), induced pluripotent stem cells (iPSC) and ependymal stem/progenitor cells (epSPC) for SCI.

引用

页数：14

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