Biaryl guanidine inhibitors of in vitro HCV-IRES activity

被引：27

作者：

Jefferson, EA ^{[1
]}

Seth, PP ^{[1
]}

Robinson, DE ^{[1
]}

Winter, DK ^{[1
]}

Miyaji, A ^{[1
]}

Osgood, SA ^{[1
]}

Swayze, EE ^{[1
]}

Risen, LM ^{[1
]}

机构：

[1] Ibis Therapeut, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

HCV-IRES; HCV; inhibitor; RNA;

D O I：

10.1016/j.bmcl.2004.07.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low muM inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5139 / 5143

页数：5

相关论文

共 22 条

[1] REDUCTION OF NITRILES TO PRIMARY AMINES WITH LITHIUM ALUMINUM HYDRIDE [J].

AMUNDSEN, LH ;

NELSON, LS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (01) :242-244

[2]

Berenguer M, 1998, ANTIVIR THER, V3, P125

[3] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].

CHOO, QL ;

KUO, G ;

WEINER, AJ ;

OVERBY, LR ;

BRADLEY, DW ;

HOUGHTON, M .

SCIENCE, 1989, 244 (4902) :359-362

[4] Hepatitis C [J].

Di Bisceglie, AM .

LANCET, 1998, 351 (9099) :351-355

[5] New therapeutic strategies for hepatitis C [J].

Di Bisceglie, AM ;

McHutchinson, J ;

Rice, CM .

HEPATOLOGY, 2002, 35 (01) :224-231

[6] The hepatitis C virus internal ribosome-entry site: A new target for antiviral research [J].

Gallego, J ;

Varani, G .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 :140-145

[7] An efficient procedure for traceless solid-phase synthesis of N,N′-substituted thioureas by thermolytic cleavage of resin-bound dithiocarbamates [J].

Gomez, L ;

Gellibert, F ;

Wagner, A ;

Mioskowski, C .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (01) :75-79

[8] Cell cycle regulation of hepatitis C virus internal ribosomal entry site-directed translation [J].

Honda, M ;

Kaneko, S ;

Matsushita, E ;

Kobayashi, K ;

Abell, GA ;

Lemon, SM .

GASTROENTEROLOGY, 2000, 118 (01) :152-162

[9] A GENERAL-METHOD FOR THE SOLID-PHASE SYNTHESIS OF UREAS [J].

HUTCHINS, SM ;

CHAPMAN, KT .

TETRAHEDRON LETTERS, 1994, 35 (24) :4055-4058

[10]

IKEDA M, 1996, Patent No. 08268890