Biaryl guanidine inhibitors of in vitro HCV-IRES activity

被引：27

作者：

Jefferson, EA ^{[1
]}

Seth, PP ^{[1
]}

Robinson, DE ^{[1
]}

Winter, DK ^{[1
]}

Miyaji, A ^{[1
]}

Osgood, SA ^{[1
]}

Swayze, EE ^{[1
]}

Risen, LM ^{[1
]}

机构：

[1] Ibis Therapeut, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

HCV-IRES; HCV; inhibitor; RNA;

D O I：

10.1016/j.bmcl.2004.07.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low muM inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5139 / 5143

页数：5

相关论文

共 22 条

[11]

Jubin R, 2001, CURR OPIN MOL THER, V3, P278

[12]

KAI YS, 1996, Patent No. 7069899

[13] DI-2-PYRIDYL THIONOCARBONATE - A NEW REAGENT FOR THE PREPARATION OF ISOTHIOCYANATES AND CARBODIIMIDES [J].

KIM, S ;

YI, KY .

TETRAHEDRON LETTERS, 1985, 26 (13) :1661-1664

[14] A simple solid-phase synthesis of disubstituted guanidines using Rink amide resin as an amine component [J].

Li, M ;

Wilson, LJ ;

Portlock, DE .

TETRAHEDRON LETTERS, 2001, 42 (12) :2273-2275

[15] Nuclease resistance of oligonucleotides containing the tricyclic cytosine analogues phenoxazine and 9-(2-aminoethoxy)-phenoxazine ("G-clamp") and origins of their nuclease resistance properties [J].

Maier, MA ;

Leeds, JM ;

Balow, G ;

Springer, RH ;

Bharadwaj, R ;

Manoharan, M .

BIOCHEMISTRY, 2002, 41 (04) :1323-1327

[16] The molecular virology of hepatitis C [J].

Major, ME ;

Feinstone, SM .

HEPATOLOGY, 1997, 25 (06) :1527-1538

[17]

Ryu KJ, 2003, J BIOCHEM MOL BIOL, V36, P538

[18] Hepatitis C therapeutics: Current status and emerging strategies [J].

Tan, SL ;

Pause, A ;

Shi, YU ;

Sonenberg, N .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (11) :867-881

[19] Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules [J].

Wang, WY ;

Préville, P ;

Morin, N ;

Mounir, S ;

Cai, WZ ;

Siddiqui, MA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (11) :1151-1154

[20] HETEROCYCLIC-COMPOUNDS .41. PREPARATION OF SUBSTITUTED 3,4-DIHYDRO-2(1H)-PYRIMIDIN-IMINES AND 2-AMINOPYRIMIDINES FROM GUANIDINE AND ALPHA,BETA-UNSATURATED KETONES [J].

WENDELIN, W ;

HARLER, A .

MONATSHEFTE FUR CHEMIE, 1975, 106 (06) :1479-1493