A novel synthesis of 2,3-disubstituted benzopyran-4-ones and application to the solid phase

被引：31

作者：

Harikrishnan, LS ^{[1
]}

Showalter, HDH ^{[1
]}

机构：

[1] Warner Lambert Co, Parke Davis Pharmaceut Res Div, Dept Chem, Ann Arbor, MI 48105 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 04期

关键词：

benzopyran-4-ones; solid-phase synthesis; traceless linker;

D O I：

10.1016/S0040-4020(99)01045-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a novel synthesis of 2,3-disubstituted benzopyran-4-ones and application to the solid phase are reported. Following model studies using benzyl alcohol as a surrogate for polystyrene hydroxymethyl resin, we utilized our previously established traceless diisopropyrsilyloxy Linker methodology to synthesize a small library of target benzopyranones in generally high yield and purity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：515 / 519

页数：5

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