The primary cilium as the cell's antenna: Signaling at a sensory organelle

被引:832
作者
Singla, Veena
Reiter, Jeremy F. [1 ]
机构
[1] Univ Calif San Francisco, Program Dev & Stem Cell Biol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
关键词
D O I
10.1126/science.1124534
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Almost every vertebrate cell has a specialized cell surface projection called a primary cilium. Although these structures were first described more than a century ago, the full scope of their functions remains poorly understood. Here, we review emerging evidence that in addition to their well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in intercellular signaling. This new appreciation of primary cilia as cellular antennae that sense a wide variety of signals could help explain why ciliary defects underlie such a wide range of human disorders, including retinal degeneration, polycystic kidney disease, Bardet-Biedl syndrome, and neural tube defects.
引用
收藏
页码:629 / 633
页数:5
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