Neurobiology of ammonia

被引:505
作者
Felipo, V
Butterworth, RF [1 ]
机构
[1] Univ Montreal, CHUM Hop St Luc, Neurosci Res Unit, Montreal, PQ H2X 3J4, Canada
[2] Fdn Valenciana Invest Biomed, Dept Neurobiol, Neurobiol Lab, Inst Invest Citol, Valencia 46010, Spain
关键词
D O I
10.1016/S0301-0082(02)00019-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hyperammonemia resulting from inherited urea cycle enzyme deficiencies or liver failure results in severe central nervous system dysfunction including brain edema, convulsions and coma. Neuropathologic evaluation in these disorders reveals characteristic alterations of astrocyte morphology ranging from cell swelling (acute hyperammonemia) to Alzheimer Type II astrocytosis (chronic hyperammonemia). Having no effective urea cycle, brain relies on glutamine systhesis for the removal of excess ammonia and the enzyme responsible, glutamine synthetase, has a predominantly astrocytic localization. Accumulation of ammonia in brain results in a redistribution of cerebral blood flow and metabolism from cortical to sub-cortical structures. In addition to changes in astrocyte morphology, increased brain ammonia concentrations result in alterations in expression of key astrocyte proteins including glial fibrillary acidic protein, glutamate and glycine transporters and "peripheral-type" (mitochondrial) benzodiazepine receptors. Such changes result in alterations of astrocytic volume and increased extracellular concentrations of excitatory and inhibitory substances. In addition, the ammonium ion has direct effects on excitatory-inhibitory transmission via distinct mechanisms involving cellular chloride extrusion and postsynaptic receptor function. Acute ammonia exposure leads to activation of NMDA receptors and their signal transduction pathways. Chronic hyperammonemia also results in increased concentrations of neuroactive L-tryptophan metabolites including serotonin and quinolinic acid. Therapy in hyperammonemic syndromes continues to rely on ammonia-lowering strategies via peripheral mechanisms (reduction of ammonia production in the gastrointestinal tract, increased ammonia removal by muscle). (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:259 / 279
页数:21
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