Effects of phorbol esters an insulin-induced activation of phosphatidylinositol 3-kinase glucose transport, and glycogen synthase in rat adipocytes

被引：15

作者：

Standaert, ML

Bandyopadhyay, G

Galloway, L

Farese, RV

机构：

[1] UNIV S FLORIDA,JA HALEY VET HOSP,RES SERV VAR151,TAMPA,FL 33612

[2] UNIV S FLORIDA,COLL MED,DEPT INTERNAL MED,TAMPA,FL 33612

[3] UNIV S FLORIDA,COLL MED,DEPT BIOCHEM,TAMPA,FL 33612

来源：

FEBS LETTERS | 1996年 / 388卷 / 01期

关键词：

insulin; phorbol ester; phosphatidylinositol; 3-kinase; glucose transport; adipocyte; IRS-1;

D O I：

10.1016/0014-5793(96)00492-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In rat adipocytes, phorbol ester-induced activation of PKC did not inhibit insulin signalling through IRS-1-dependent phosphatidylinositol (PI) 3-kinase activation, Moreover, phorbol esters alone provoked an increase in membrane PI 3-kinase activity, These findings may be relevant to the failure of phorbol esters to inhibit insulin effects on glucose transport and glycogen synthesis in rat adipocytes.

引用

页码：26 / 28

页数：3

共 18 条

[11] NAVE BT, 1995, BIOCH SOC TRANS, V23, pS189
[12] OKADA T, 1994, J BIOL CHEM, V269, P3568
[13] INSULIN-MIMETIC ACTIONS OF PHORBOL ESTER IN CULTURED ADULT-RAT HEPATOCYTES - LACK OF PHORBOL-ESTER-ELICITED INHIBITION OF THE INSULIN SIGNAL
QUENTMEIER, A
DANESCHMAND, H
KLEIN, H
UNTHANFECHNER, K
PROBST, I
[J]. BIOCHEMICAL JOURNAL, 1993, 289 : 549 - 555
[14] SALTIS J, 1991, J BIOL CHEM, V266, P261
[15] MINIMAL EFFECTS OF PHORBOL ESTERS ON GLUCOSE-TRANSPORT AND INSULIN SENSITIVITY OF RAT SKELETAL-MUSCLE
SOWELL, MO
TREUTELAAR, MK
BURANT, CF
BUSE, MG
[J]. DIABETES, 1988, 37 (05) : 499 - 506
[16] STUDIES WITH WORTMANNIN SUGGEST A ROLE FOR PHOSPHATIDYLINOSITOL 3-KINASE IN THE ACTIVATION OF GLYCOGEN-SYNTHASE AND MITOGEN-ACTIVATED PROTEIN-KINASE BY INSULIN IN RAT ADIPOCYTES - COMPARISON OF INSULIN AND PROTEIN-KINASE-C MODULATORS
STANDAERT, ML
BANDYOPADHYAY, G
FARESE, RV
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 209 (03) : 1082 - 1088
[17] The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes
Standaert, ML
Avignon, A
Yamada, K
Bandyopadhyay, G
Farese, RV
[J]. BIOCHEMICAL JOURNAL, 1996, 313 : 1039 - 1046
[18] TANTI JF, 1994, J BIOL CHEM, V269, P6051

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