Synthesis and in vitro cytotoxicity of cryptophycins and related analogs

被引：25

作者：

deMuys, JM ^{[1
]}

Rej, R ^{[1
]}

Nguyen, D ^{[1
]}

Go, B ^{[1
]}

Fortin, S ^{[1
]}

Lavallee, JF ^{[1
]}

机构：

[1] BIOCHEM THERAPEUT INC,LAVAL,PQ H7V 4A7,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 10期

关键词：

D O I：

10.1016/0960-894X(96)00182-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several members of the Cryptophycin family were synthesised using a straightforward convergent approach, The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines. (C) 1996 Elsevier Science Ltd

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页码：1111 / 1116

页数：6

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