NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes

被引：47

作者：

An, Omer ^{[1
]}

Pendino, Vera ^{[1
]}

D'Antonio, Matteo ^{[1
]}

Ratti, Emanuele ^{[1
]}

Gentilini, Marco ^{[1
]}

Ciccarelli, Francesca D. ^{[1
,2
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

[2] Kings Coll London, Div Canc Studies, London SE1 1UL, England

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2014年

关键词：

ACUTE MYELOID-LEUKEMIA; IDENTIFIES RECURRENT MUTATIONS; CHROMATIN REMODELING GENES; HUMAN PANCREATIC CANCERS; SOMATIC MUTATIONS; FREQUENT MUTATION; INACTIVATING MUTATIONS; INTERACTION DATABASE; INTEGRATED ANALYSIS; DRIVER MUTATIONS;

D O I：

10.1093/database/bau015

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones.

引用

页数：10

共 111 条

[1]

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

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Wheeler, David A. ;

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Cibulskis, Kristian ;

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Frederick, Abbie M. ;

Lawrence, Michael S. ;

Sivachenko, Andrey Y. ;

Sougnez, Carrie ;

Zou, Lihua ;

Cortes, Maria L. ;

Fernandez-Lopez, Juan C. ;

Peng, Shouyong ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Bautista-Pina, Veronica ;

Duke, Fujiko ;

Francis, Joshua ;

Jung, Joonil ;

Maffuz-Aziz, Antonio ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Pho, Nam H. ;

Quintanar-Jurado, Valeria ;

Ramos, Alex H. ;

Rebollar-Vega, Rosa ;

Rodriguez-Cuevas, Sergio ;

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Schumacher, Steven E. ;

Stransky, Nicolas ;

Thompson, Kristin M. ;

Uribe-Figueroa, Laura ;

Baselga, Jose ;

Beroukhim, Rameen ;

Polyak, Kornelia ;

Sgroi, Dennis C. ;

Richardson, Andrea L. ;

Jimenez-Sanchez, Gerardo ;

Lander, Eric S. ;

Gabriel, Stacey B. ;

Garraway, Levi A. ;

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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

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Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy [J].

Barretina, Jordi ;

Taylor, Barry S. ;

Banerji, Shantanu ;

Ramos, Alexis H. ;

Lagos-Quintana, Mariana ;

DeCarolis, Penelope L. ;

Shah, Kinjal ;

Socci, Nicholas D. ;

Weir, Barbara A. ;

Ho, Alan ;

Chiang, Derek Y. ;

Reva, Boris ;

Mermel, Craig H. ;

Getz, Gad ;

Antipin, Yevgenyi ;

Beroukhim, Rameen ;

Major, John E. ;

Hatton, Charles ;

Nicoletti, Richard ;

Hanna, Megan ;

Sharpe, Ted ;

Fennell, Tim J. ;

Cibulskis, Kristian ;

Onofrio, Robert C. ;

Saito, Tsuyoshi ;

Shukla, Neerav ;

Lau, Christopher ;

Nelander, Sven ;

Silver, Serena J. ;

Sougnez, Carrie ;

Viale, Agnes ;

Winckler, Wendy ;

Maki, Robert G. ;

Garraway, Levi A. ;

Lash, Alex ;

Greulich, Heidi ;

Root, David E. ;

Sellers, William R. ;

Schwartz, Gary K. ;

Antonescu, Cristina R. ;

Lander, Eric S. ;

Varmus, Harold E. ;

Ladanyi, Marc ;

Sander, Chris ;

Meyerson, Matthew ;

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MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

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Melanoma genome sequencing reveals frequent PREX2 mutations [J].

Berger, Michael F. ;

Hodis, Eran ;

Heffernan, Timothy P. ;

Deribe, Yonathan Lissanu ;

Lawrence, Michael S. ;

Protopopov, Alexei ;

Ivanova, Elena ;

Watson, Ian R. ;

Nickerson, Elizabeth ;

Ghosh, Papia ;

Zhang, Hailei ;

Zeid, Rhamy ;

Ren, Xiaojia ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Wagle, Nikhil ;

Sucker, Antje ;

Sougnez, Carrie ;

Onofrio, Robert ;

Ambrogio, Lauren ;

Auclair, Daniel ;

Fennell, Timothy ;

Carter, Scott L. ;

Drier, Yotam ;

Stojanov, Petar ;

Singer, Meredith A. ;

Voet, Douglas ;

Jing, Rui ;

Saksena, Gordon ;

Barretina, Jordi ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Stransky, Nicolas ;

Parkin, Melissa ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Wargo, Jennifer ;

Schadendorf, Dirk ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Wagner, Stephan N. ;

Lander, Eric S. ;

Getz, Gad ;

Chin, Lynda ;

Garraway, Levi A. .

NATURE, 2012, 485 (7399) :502-506

[7]

The genomic complexity of primary human prostate cancer [J].

Berger, Michael F. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Drier, Yotam ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Sboner, Andrea ;

Esgueva, Raquel ;

Pflueger, Dorothee ;

Sougnez, Carrie ;

Onofrio, Robert ;

Carter, Scott L. ;

Park, Kyung ;

Habegger, Lukas ;

Ambrogio, Lauren ;

Fennell, Timothy ;

Parkin, Melissa ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Wilkinson, Jane ;

Fisher, Sheila ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Simons, Jonathan W. ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Kantoff, Philip W. ;

Chin, Lynda ;

Gabriel, Stacey B. ;

Gerstein, Mark B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Tewari, Ashutosh ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE, 2011, 470 (7333) :214-220

[8]

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma [J].

Bettegowda, Chetan ;

Agrawal, Nishant ;

Jiao, Yuchen ;

Sausen, Mark ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Rodriguez, Fausto J. ;

Cahill, Daniel P. ;

McLendon, Roger ;

Riggins, Gregory ;

Velculescu, Victor E. ;

Oba-Shinjo, Sueli Mieko ;

Marie, Suely Kazue Nagahashi ;

Vogelstein, Bert ;

Bigner, Darell ;

Yan, Hai ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. .

SCIENCE, 2011, 333 (6048) :1453-1455

[9]

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes [J].

Biankin, Andrew V. ;

Waddell, Nicola ;

Kassahn, Karin S. ;

Gingras, Marie-Claude ;

Muthuswamy, Lakshmi B. ;

Johns, Amber L. ;

Miller, David K. ;

Wilson, Peter J. ;

Patch, Ann-Marie ;

Wu, Jianmin ;

Chang, David K. ;

Cowley, Mark J. ;

Gardiner, Brooke B. ;

Song, Sarah ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Manning, Suzanne ;

Wani, Shivangi ;

Gongora, Milena ;

Pajic, Marina ;

Scarlett, Christopher J. ;

Gill, Anthony J. ;

Pinho, Andreia V. ;

Rooman, Ilse ;

Anderson, Matthew ;

Holmes, Oliver ;

Leonard, Conrad ;

Taylor, Darrin ;

Wood, Scott ;

Xu, Qinying ;

Nones, Katia ;

Fink, J. Lynn ;

Christ, Angelika ;

Bruxner, Tim ;

Cloonan, Nicole ;

Kolle, Gabriel ;

Newell, Felicity ;

Pinese, Mark ;

Mead, R. Scott ;

Humphris, Jeremy L. ;

Kaplan, Warren ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chou, Angela ;

Chin, Venessa T. ;

Chantrill, Lorraine A. .

NATURE, 2012, 491 (7424) :399-405

[10]

Gene Ontology Annotations and Resources [J].

Blake, J. A. ;

Dolan, M. ;

Drabkin, H. ;

Hill, D. P. ;

Ni, Li ;

Sitnikov, D. ;

Bridges, S. ;

Burgess, S. ;

Buza, T. ;

McCarthy, F. ;

Peddinti, D. ;

Pillai, L. ;

Carbon, S. ;

Dietze, H. ;

Ireland, A. ;

Lewis, S. E. ;

Mungall, C. J. ;

Gaudet, P. ;

Chisholm, R. L. ;

Fey, P. ;

Kibbe, W. A. ;

Basu, S. ;

Siegele, D. A. ;

McIntosh, B. K. ;

Renfro, D. P. ;

Zweifel, A. E. ;

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Apweiler, R. ;

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Blatter, M-C. ;

Bonilla, C. ;

Bougueleret, L. ;

Boutet, E. ;

Breuza, L. ;

Bridge, A. ;

Chan, W. M. ;

Chavali, G. ;

Coudert, E. ;

Dimmer, E. ;

Estreicher, A. ;

Famiglietti, L. ;

Feuermann, M. ;

Gos, A. ;

Gruaz-Gumowski, N. ;

Hieta, R. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D530-D535

← 1 2 3 4 5 6 7 8 9 10 →

共 111 条

[1]

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[2]

Sequence analysis of mutations and translocations across breast cancer subtypes [J].

Banerji, Shantanu ;

Cibulskis, Kristian ;

Rangel-Escareno, Claudia ;

Brown, Kristin K. ;

Carter, Scott L. ;

Frederick, Abbie M. ;

Lawrence, Michael S. ;

Sivachenko, Andrey Y. ;

Sougnez, Carrie ;

Zou, Lihua ;

Cortes, Maria L. ;

Fernandez-Lopez, Juan C. ;

Peng, Shouyong ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Bautista-Pina, Veronica ;

Duke, Fujiko ;

Francis, Joshua ;

Jung, Joonil ;

Maffuz-Aziz, Antonio ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Pho, Nam H. ;

Quintanar-Jurado, Valeria ;

Ramos, Alex H. ;

Rebollar-Vega, Rosa ;

Rodriguez-Cuevas, Sergio ;

Romero-Cordoba, Sandra L. ;

Schumacher, Steven E. ;

Stransky, Nicolas ;

Thompson, Kristin M. ;

Uribe-Figueroa, Laura ;

Baselga, Jose ;

Beroukhim, Rameen ;

Polyak, Kornelia ;

Sgroi, Dennis C. ;

Richardson, Andrea L. ;

Jimenez-Sanchez, Gerardo ;

Lander, Eric S. ;

Gabriel, Stacey B. ;

Garraway, Levi A. ;

Golub, Todd R. ;

Melendez-Zajgla, Jorge ;

Toker, Alex ;

Getz, Gad ;

Hidalgo-Miranda, Alfredo ;

Meyerson, Matthew .

NATURE, 2012, 486 (7403) :405-409

[3]

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[4]

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy [J].

Barretina, Jordi ;

Taylor, Barry S. ;

Banerji, Shantanu ;

Ramos, Alexis H. ;

Lagos-Quintana, Mariana ;

DeCarolis, Penelope L. ;

Shah, Kinjal ;

Socci, Nicholas D. ;

Weir, Barbara A. ;

Ho, Alan ;

Chiang, Derek Y. ;

Reva, Boris ;

Mermel, Craig H. ;

Getz, Gad ;

Antipin, Yevgenyi ;

Beroukhim, Rameen ;

Major, John E. ;

Hatton, Charles ;

Nicoletti, Richard ;

Hanna, Megan ;

Sharpe, Ted ;

Fennell, Tim J. ;

Cibulskis, Kristian ;

Onofrio, Robert C. ;

Saito, Tsuyoshi ;

Shukla, Neerav ;

Lau, Christopher ;

Nelander, Sven ;

Silver, Serena J. ;

Sougnez, Carrie ;

Viale, Agnes ;

Winckler, Wendy ;

Maki, Robert G. ;

Garraway, Levi A. ;

Lash, Alex ;

Greulich, Heidi ;

Root, David E. ;

Sellers, William R. ;

Schwartz, Gary K. ;

Antonescu, Cristina R. ;

Lander, Eric S. ;

Varmus, Harold E. ;

Ladanyi, Marc ;

Sander, Chris ;

Meyerson, Matthew ;

Singer, Samuel .

NATURE GENETICS, 2010, 42 (08) :715-U103

[5]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6]

Melanoma genome sequencing reveals frequent PREX2 mutations [J].

Berger, Michael F. ;

Hodis, Eran ;

Heffernan, Timothy P. ;

Deribe, Yonathan Lissanu ;

Lawrence, Michael S. ;

Protopopov, Alexei ;

Ivanova, Elena ;

Watson, Ian R. ;

Nickerson, Elizabeth ;

Ghosh, Papia ;

Zhang, Hailei ;

Zeid, Rhamy ;

Ren, Xiaojia ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Wagle, Nikhil ;

Sucker, Antje ;

Sougnez, Carrie ;

Onofrio, Robert ;

Ambrogio, Lauren ;

Auclair, Daniel ;

Fennell, Timothy ;

Carter, Scott L. ;

Drier, Yotam ;

Stojanov, Petar ;

Singer, Meredith A. ;

Voet, Douglas ;

Jing, Rui ;

Saksena, Gordon ;

Barretina, Jordi ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Stransky, Nicolas ;

Parkin, Melissa ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Wargo, Jennifer ;

Schadendorf, Dirk ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Wagner, Stephan N. ;

Lander, Eric S. ;

Getz, Gad ;

Chin, Lynda ;

Garraway, Levi A. .

NATURE, 2012, 485 (7399) :502-506

[7]

The genomic complexity of primary human prostate cancer [J].

Berger, Michael F. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Drier, Yotam ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Sboner, Andrea ;

Esgueva, Raquel ;

Pflueger, Dorothee ;

Sougnez, Carrie ;

Onofrio, Robert ;

Carter, Scott L. ;

Park, Kyung ;

Habegger, Lukas ;

Ambrogio, Lauren ;

Fennell, Timothy ;

Parkin, Melissa ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Wilkinson, Jane ;

Fisher, Sheila ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Simons, Jonathan W. ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Kantoff, Philip W. ;

Chin, Lynda ;

Gabriel, Stacey B. ;

Gerstein, Mark B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Tewari, Ashutosh ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE, 2011, 470 (7333) :214-220

[8]

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma [J].

Bettegowda, Chetan ;

Agrawal, Nishant ;

Jiao, Yuchen ;

Sausen, Mark ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Rodriguez, Fausto J. ;

Cahill, Daniel P. ;

McLendon, Roger ;

Riggins, Gregory ;

Velculescu, Victor E. ;

Oba-Shinjo, Sueli Mieko ;

Marie, Suely Kazue Nagahashi ;

Vogelstein, Bert ;

Bigner, Darell ;

Yan, Hai ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. .

SCIENCE, 2011, 333 (6048) :1453-1455

[9]

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes [J].

Biankin, Andrew V. ;

Waddell, Nicola ;

Kassahn, Karin S. ;

Gingras, Marie-Claude ;

Muthuswamy, Lakshmi B. ;

Johns, Amber L. ;

Miller, David K. ;

Wilson, Peter J. ;

Patch, Ann-Marie ;

Wu, Jianmin ;

Chang, David K. ;

Cowley, Mark J. ;

Gardiner, Brooke B. ;

Song, Sarah ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Manning, Suzanne ;

Wani, Shivangi ;

Gongora, Milena ;

Pajic, Marina ;

Scarlett, Christopher J. ;

Gill, Anthony J. ;

Pinho, Andreia V. ;

Rooman, Ilse ;

Anderson, Matthew ;

Holmes, Oliver ;

Leonard, Conrad ;

Taylor, Darrin ;

Wood, Scott ;

Xu, Qinying ;

Nones, Katia ;

Fink, J. Lynn ;

Christ, Angelika ;

Bruxner, Tim ;

Cloonan, Nicole ;

Kolle, Gabriel ;

Newell, Felicity ;

Pinese, Mark ;

Mead, R. Scott ;

Humphris, Jeremy L. ;

Kaplan, Warren ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chou, Angela ;

Chin, Venessa T. ;

Chantrill, Lorraine A. .

NATURE, 2012, 491 (7424) :399-405

[10]

Gene Ontology Annotations and Resources [J].

Blake, J. A. ;

Dolan, M. ;

Drabkin, H. ;

Hill, D. P. ;

Ni, Li ;

Sitnikov, D. ;

Bridges, S. ;

Burgess, S. ;

Buza, T. ;

McCarthy, F. ;

Peddinti, D. ;

Pillai, L. ;

Carbon, S. ;

Dietze, H. ;

Ireland, A. ;

Lewis, S. E. ;

Mungall, C. J. ;

Gaudet, P. ;

Chisholm, R. L. ;

Fey, P. ;

Kibbe, W. A. ;

Basu, S. ;

Siegele, D. A. ;

McIntosh, B. K. ;

Renfro, D. P. ;

Zweifel, A. E. ;

Hu, J. C. ;

Brown, N. H. ;

Tweedie, S. ;

Alam-Faruque, Y. ;

Apweiler, R. ;

Auchinchloss, A. ;

Axelsen, K. ;

Bely, B. ;

Blatter, M-C. ;

Bonilla, C. ;

Bougueleret, L. ;

Boutet, E. ;

Breuza, L. ;

Bridge, A. ;

Chan, W. M. ;

Chavali, G. ;

Coudert, E. ;

Dimmer, E. ;

Estreicher, A. ;

Famiglietti, L. ;

Feuermann, M. ;

Gos, A. ;

Gruaz-Gumowski, N. ;

Hieta, R. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D530-D535

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