Microwave-assisted direct biaryl coupling: first application to the synthesis of aporphines

被引：27

作者：

Chaudhary, Sandeep

Pecic, Stevan

LeGendre, Onica

Harding, Wayne W. ^{[1
]}

机构：

[1] NYU, Dept Chem, Hunter Coll, New York, NY 10065 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 20期

基金：

美国国家卫生研究院;

关键词：

H BOND ACTIVATION; DIRECT ARYLATION; (+/-)-NANTENINE DERIVATIVES; ORGANIC-SYNTHESIS; DRUG DISCOVERY; HETEROCYCLES; ALKALOIDS; CATALYSIS; IMPACT; ARYL;

D O I：

10.1016/j.tetlet.2009.03.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have investigated the use of microwaves in a direct biaryl Coupling reaction for the synthesis of analogs of the aporphine alkaloid nantenine. Our Study shows that the aporphine core may be rapidly accessed from benzyl-tetrahydroisoquinoline substrates with this method. This is the first report of a microwave-assisted direct biaryl coupling reaction in the synthesis of aporphine molecules. (C) 2009 Elsevier Ltd. All rights reserved.

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页码：2437 / 2439

页数：3

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