Linezolid treatment of vancomycin-resistant Enterococcus faecium ventriculitis

被引：44

作者：

Graham, PL

Ampofo, K

Saiman, L

机构：

[1] Columbia Univ, Dept Pediat, New York, NY 10032 USA

[2] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2002年 / 21卷 / 08期

关键词：

vancomycin-resistant enterococci; ventriculitis; linezolid;

D O I：

10.1097/00006454-200208000-00025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The successful treatment of a 7-month-old infant with shunt-associated ventriculitis caused by vancomycin-resistant Enterococcus faecium is presented. Linezolid was administered intravenously every 8 h; children have a greater volume of distribution and total body clearance than adults and therefore require more frequent dosing. The patient tolerated the therapy without adverse effects.

引用

收藏

页码：798 / 800

页数：3

相关论文

共 22 条

[1] Vancomycin-resistant enterococci in the pediatric patient [J].

Bratcher, DF .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2001, 20 (06) :621-622

[2] Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections [J].

Chien, JW ;

Kucia, ML ;

Salata, RA .

CLINICAL INFECTIOUS DISEASES, 2000, 30 (01) :146-151

[3]

CHIMA CO, 2002, SOC HEALTHC EP AM AN

[4] Vancomycin-resistant enterococci: Mechanisms and clinical observations [J].

Gold, HS .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (02) :210-219

[5] Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid [J].

Gonzales, RD ;

Schreckenberger, PC ;

Graham, MB ;

Kelkar, S ;

DenBesten, K ;

Quinn, JP .

LANCET, 2001, 357 (9263) :1179-1179

[6]

Gransden WR, 1998, ARCH DIS CHILD-FETAL, V78, pF235

[7] Nosocomial spread of linezolid-resistant, vancomycin-resistant enterococcus faecium [J].

Herrero, IA ;

Issa, NC ;

Patel, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (11) :867-869

[8] Single dose pharmacokinetics of linezolid in infants and children [J].

Kearns, GL ;

Abdel-Rahman, SM ;

Blumer, JL ;

Reed, MD ;

James, LP ;

Jacobs, RF ;

Welshman, IR ;

Jungbluth, GL ;

Stalker, DJ .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (12) :1178-1184

[9] SUCCESSFUL TREATMENT OF MENINGITIS DUE TO MULTIPLY RESISTANT ENTEROCOCCUS-FAECIUM WITH A COMBINATION OF INTRATHECAL TEICOPLANIN AND INTRAVENOUS ANTIMICROBIAL AGENTS [J].

LOSONSKY, GA ;

WOLF, A ;

SCHWALBE, RS ;

NATARO, J ;

GIBSON, CB ;

LEWIS, EW .

CLINICAL INFECTIOUS DISEASES, 1994, 19 (01) :163-165

[10] Vancomycin-resistant Enterococcus faecium meningitis successfully treated with chloramphenicol [J].

Mato, SP ;

Robinson, S ;

Bégué, RE .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1999, 18 (05) :483-484