Histone lysine methylation in genomic imprinting

被引：14

作者：

Ciccone, David N. ^{[1
]}

Chen, Taiping ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

来源：

EPIGENETICS | 2009年 / 4卷 / 04期

关键词：

genomic imprinting; DNA methylation; lysine methylation; chromatin; Dnmt; Zfp57; ZINC-FINGER PROTEINS; EMBRYONIC STEM-CELLS; DE-NOVO METHYLATION; DNA METHYLATION; H3; METHYLTRANSFERASE; EARLY EMBRYOGENESIS; EFFECT GENE; DNMT3L; ESTABLISHMENT; DOMAIN;

D O I：

10.4161/epi.8974

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic imprinting is an epigenetic phenomenon that causes parent-of-origin-specific expression of a small subset of genes in mammals. DNA methylation is believed to be the primary epigenetic signal that controls genomic imprinting. These methylation imprints are established during gametogenesis in male and female germ cells and maintained and interpreted during embryogenesis and in somatic tissues. Based on recent studies, histone lysine methylation plays an important role in the regulation of imprinted gene expression and, more intriguingly, may also be involved in the establishment and maintenance of DNA methylation imprints. In this point of view, we discuss these studies and their implications.

引用

页码：216 / 220

页数：5

共 38 条

[31] DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction [J].