Rejuvenation of the aging T cell compartment

被引：50

作者：

Holland, Amanda M. ^{[1
,2
,3
]}

van den Brink, Marcel R. M. ^{[1
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Immunol & Microbial Pathogenesis, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Immunol, New York, NY 10065 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

BONE-MARROW-TRANSPLANTATION; KERATINOCYTE GROWTH-FACTOR; BLOOD MONONUCLEAR-CELLS; IMMUNE RECONSTITUTION; IN-VIVO; THYMIC REGENERATION; HORMONE RECEPTORS; ANDROGEN BLOCKADE; MEMORY CELLS; IL-7;

D O I：

10.1016/j.coi.2009.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The elderly face significant risk for susceptibility to infection and cancer because of declining immune function. Various agents used in the setting of bone marrow transplantation and aging studies represent promising approaches to combating T cell defects in the aging population. Preclinical and clinical studies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be used to alleviate the effects of T cell deficiencies in the elderly.

引用

页码：454 / 459

页数：6

共 68 条

[1]

AbdulHai A, 1996, EXP HEMATOL, V24, P1416

[2] Memory T cell homeostasis and senescence during aging [J].

Akbar, AN ;

Fletcher, JM .

CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (05) :480-485

[3] Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration [J].

Alpdogan, Ö ;

Hubbard, VM ;

Smith, OM ;

Patel, N ;

Lu, S ;

Goldberg, GL ;

Gray, DH ;

Feinman, J ;

Kochman, AA ;

Eng, JM ;

Suh, D ;

Muriglan, SJ ;

Boyd, RL ;

van den Brink, MRM .

BLOOD, 2006, 107 (06) :2453-2460

[4] Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation [J].

Alpdogan, O ;

Eng, JM ;

Muriglan, SJ ;

Willis, LM ;

Hubbard, VM ;

Tjoe, KH ;

Terwey, T ;

Kochman, A ;

van den Brink, MRM .

BLOOD, 2005, 105 (02) :865-873

[5] Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease [J].

Alpdogan, O ;

Schmaltz, C ;

Muriglan, SJ ;

Kappel, BJ ;

Perales, MA ;

Rotolo, JA ;

Halm, JA ;

Rich, BE ;

van den Brink, MRM .

BLOOD, 2001, 98 (07) :2256-2265

[6] IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation [J].

Alpdogan, Ö ;

Muriglan, SJ ;

Eng, JM ;

Willis, LM ;

Greenberg, AS ;

Kappel, B ;

van den Brink, MRM .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (07) :1095-1107

[7] Insulin-like growth factor-I enhances lymphoid and myeloid reconstitution after allogeneic bone marrow transplantation. [J].

Alpdogan, Ö ;

Muriglan, SJ ;

Kappel, BJ ;

Doubrovina, E ;

Schmaltz, C ;

Schiro, R ;

Eng, JM ;

Greenberg, AS ;

Willis, LM ;

Rotolo, JA ;

O'Reilly, RJ ;

van den Brink, MRM .

TRANSPLANTATION, 2003, 75 (12) :1977-1983

[8] Haematopoietic cell transplantation as immunotherapy [J].

Appelbaum, FR .

NATURE, 2001, 411 (6835) :385-389

[9]

Bolotin E, 1996, BLOOD, V88, P1887

[10] Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: Relation with age and GH-binding protein [J].

Bresson, JL ;

Jeay, S ;

Gagnerault, MC ;

Kayser, C ;

Beressi, N ;

Wu, ZD ;

Kinet, S ;

Dardenne, M ;

Postel-Vinay, MC .

ENDOCRINOLOGY, 1999, 140 (07) :3203-3209

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