Antiemetic principles of Alpinia officinarum

被引：87

作者：

Shin, D ^{[1
]}

Kinoshita, K ^{[1
]}

Koyama, K ^{[1
]}

Takahashi, K ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, Kiyose, Tokyo 2048588, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 09期

关键词：

D O I：

10.1021/np020099i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioasay-guided fractionation of the antiemetic constituents of Alpinia officinarum was performed, and eight compounds (1-8) including a new compound were isolated. Among the seven known compounds, two flavonoids (1, 2), four diarylheptanoids (3, 5, 6, 8), and one sterol (4) were obtained, with five (2-6) of those compounds showing antiemetic activity in a copper sulfate induced emesis assay in young chicks. The structure of the new compound 7, which also showed antiemetic activity, was determined as 5-hydroxy7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-3-heptanone. The structure of 7 was established on the basis of spectroscopic data interpretation.

引用

页码：1315 / 1318

页数：4

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