Tumor cell cytolysis mediated by valorphin, an opioid-like fragment of hemoglobin beta-chain

被引：23

作者：

Blishchenko, EY

Mernenko, OA

Mirkina, II

Satpaev, DK

Ivanov, VS

Tchikin, LD

Ostrovsky, AG

Karelin, AA

Ivanov, VT

机构：

[1] Shemyakin-Ovchinnikov Inst. of B., 117871 Moscow V-437

来源：

PEPTIDES | 1997年 / 18卷 / 01期

关键词：

valorphin; cytotoxicity; hemorphins; necrosis; naloxone;

D O I：

10.1016/S0196-9781(96)00248-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Valorphin, an endogenous opioid-like hemoglobin fragment, is cytotoxic for L929 and K562 tumor cells in 10(-7)-10(-13) M concentration range. Because cytolytic effects induced by valorphin in K562 cells are inhibited by naloxone, opioid receptors should be involved in induction of valorphin-mediated tumor cell death. Three distinct cytolytic processes, differing in the onset time and the development time, take place with K562 cells within 10-18 h of incubation with valorphin. All three processes are not associated with apoptotic mechanism of cell death. (C) 1997 Elsevier Science Inc.

引用

页码：79 / 85

页数：7

共 37 条

[1]

AHARONY D, 1991, J PHARMACOL EXP THER, V259, P146

[2] NK-LYSIN, A NOVEL EFFECTOR PEPTIDE OF CYTOTOXIC T-CELLS AND NK-CELLS - STRUCTURE AND CDNA CLONING OF THE PORCINE FORM, INDUCTION BY INTERLEUKIN-2, ANTIBACTERIAL AND ANTITUMOR-ACTIVITY [J].