Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis

被引:140
作者
Anderson, GG
Dodson, KW
Hooton, TM
Hultgren, SJ
机构
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[2] Univ Washington, Sch Med, Dept Med, Div Allergy & Infect Dis, Seattle, WA 98104 USA
关键词
D O I
10.1016/j.tim.2004.07.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Urinary tract infections in young, healthy women frequently recur, despite their traditional classification as acute infections. Conventional wisdom dictates that uropathogens causing recurrent infections in such individuals come from the fecal or vaginal flora, in the same manner as the initial infection. However, recent studies of uropathogenic Escherichia coli have found that it can carry out a complex developmental program within the superficial epithelial cells of the mouse bladder, forming intracellullar bacterial communities with many biofilm-like properties. These intracellular biofilms allow the bacteria to outlast a strong host immune response to establish a dormant reservoir of pathogens inside the bladder cells. Re-emergence of bacteria from this reservoir might be the source of recurrent infection.
引用
收藏
页码:424 / 430
页数:7
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