The role of leptin in the control of body weight

被引：129

作者：

Leibel, RL

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Pediat, Div Mol Genet, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Naomi Berrie Diabet Ctr, Div Mol Genet, New York, NY 10032 USA

来源：

NUTRITION REVIEWS | 2002年 / 60卷 / 10期

关键词：

leptin concentrations; counterregulatory responses; energy balance; weight; obesity;

D O I：

10.1301/002966402320634788

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Physiologic responses to high and low leptin concentrations are strikingly asymmetrical. High concentrations often produce minimal effects, whereas low concentrations provoke strong counterregulatory responses. A model and rationale for the physiology is presented.

引用

页码：S15 / S19

页数：5

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