Small Molecule Inhibitors of AKT/PKB Kinase as a Strategy for Treating Cancer

被引：14

作者：

Heerding, Dirk A. ^{[1
]}

Safonov, Igor G. ^{[1
]}

Verma, Sharad K. ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Collegeville, PA 19426 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 42 | 2007年 / 42卷

关键词：

D O I：

10.1016/S0065-7743(07)42023-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：365 / 376

页数：12

共 71 条

[1] Perturbations of the AKT signaling pathway in human cancer
Altomare, DA
Testa, JR
[J]. ONCOGENE, 2005, 24 (50) : 7455 - 7464
[2] Barda D. A., 2005, [No title captured], Patent No. [2005054202, WO/2005/054202 A1]
[3] Regulation of Akt/PKB Ser473 phosphorylation
Bayascas, JR
Alessi, DR
[J]. MOLECULAR CELL, 2005, 18 (02) : 143 - 145
[4] Activation of AKT kinases in cancer: Implications for therapeutic targeting
Bellacosa, A
Kumar, CC
Di Cristofano, A
Testa, JR
[J]. ADVANCES IN CANCER RESEARCH, VOL 94, 2005, 94 : 29 - +
[5] BERDINI V, 2006, Patent No. 2006046023
[6] Berdini V., 2006, WO, Patent No. 2006046024
[7] Capraro H. -G., 2005, WO, Patent No. [2005054237, 2005/054237A1]
[8] CHEE KG, 2005, 41 ANN M ASCO ORL FL
[9] SYNTHESIS OF CERTAIN [6-5-6] LINEAR TRICYCLIC NUCLEOSIDES AS POTENTIAL ANTI-TUMOR AGENTS
CHUNG, FL
SCHRAM, KH
PANZICA, RP
EARL, RA
WOTRING, LL
TOWNSEND, LB
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) : 1158 - 1166
[10] COBB WR, 1983, CANCER TREAT REP, V67, P173