Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

被引：173

作者：

Bao, Mei-Hua ^{[1
,2
]}

Feng, Xing ^{[3
]}

Zhang, Yi-Wen ^{[1
]}

Lou, Xiao-Ya ^{[1
]}

Cheng, Yu ^{[1
]}

Zhou, Hong-Hao ^{[1
]}

机构：

[1] Cent South Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

[2] Changsha Med Univ, Dept Pharm, Changsha 410219, Hunan, Peoples R China

[3] Hunan Normal Univ, Coll Med, Changsha 410006, Hunan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 11期

关键词：

let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker; TO-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION; CIRCULATING MICRORNAS; CHANNEL GENES; OX-LDL; RNA; DICER; TOLL-LIKE-RECEPTOR-4; ANGIOGENESIS; CONTRIBUTES;

D O I：

10.3390/ijms141123086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.

引用

页码：23086 / 23102

页数：17

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