A terminal affair:: 3′-end recognition by the human La protein

被引：15

作者：

Curry, Stephen

Conte, Maria R.

机构：

[1] Kings Coll, Randall Div Cell & Mol Biophys, London SE1 1UL, England

[2] Univ London Imperial Coll Sci Technol & Med, Fac Nat Sci, Blackett Lab, Biophys Sect, London SW7 2AZ, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.tibs.2006.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The La protein, an autoantigen in rheumatic disease, orchestrates several aspects of the metabolism of noncoding RNA molecules. More than 20 years ago it was shown that La primarily binds the 3' UUU-OH tails of nascent transcripts of RNA polymerase Ill. A recent study now reveals how the structure of the amino-terminal domain of the human La protein achieves specific 3'-end recognition.

引用

页码：303 / 305

页数：3

共 24 条

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