Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication

被引：102

作者：

Laskus, T

Radkowski, M

Wang, LF

Nowicki, M

Rakela, J

机构：

[1] Univ Pittsburgh, Med Ctr, Div Gastroenterol & Hepatol, Pittsburgh, PA 15213 USA

[2] Med Acad Warsaw, Inst Infect Dis, Warsaw, Poland

[3] Univ So Calif, Maternal Child Virol Res Lab, Los Angeles, CA 90033 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 02期

关键词：

D O I：

10.1128/JVI.74.2.1014-1017.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

引用

收藏

页码：1014 / 1017

页数：4

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