Four new members expand the interleukin-1 superfamily

被引：288

作者：

Smith, DE ^{[1
]}

Renshaw, BR ^{[1
]}

Ketchem, RR ^{[1
]}

Kubin, M ^{[1
]}

Garka, KE ^{[1
]}

Sims, JE ^{[1
]}

机构：

[1] Immunex Corp, Seattle, WA 98101 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2000年 / 275卷 / 02期

关键词：

D O I：

10.1074/jbc.275.2.1169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1 delta, FIL1 epsilon, FIL1 zeta and FLI1 eta, with FIL1 standing for "Family of IL-1"), The novel genes demonstrate significant sequence similarity to IL-1 alpha, IL-1 beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1 beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

引用

页码：1169 / 1175

页数：7

共 42 条

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