Aurora kinase inhibitors: A new class of targeted drugs in cancer

被引：27

作者：

Gautschi, Oliver ^{[1
]}

Mack, Philip C. ^{[1
]}

Davies, Angela M. ^{[1
]}

Lara, Primo N., Jr. ^{[1
]}

Gandara, David R. ^{[1
]}

机构：

[1] Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USA

来源：

CLINICAL LUNG CANCER | 2006年 / 8卷 / 02期

关键词：

AZD1152; mitotic kinases; MK-0457; MLN8054;

D O I：

10.3816/CLC.2006.n.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aurora kinases (A, B, and Q are essential for spindle assembly, centrosome maturation, chromosomal segregation, and cytokinesis. Aurora kinases A and B are overexpressed in many cancers, including non-small-cell lung cancer and mesothehoma. Small-molecule inhibitors selective for aurora kinases have shown promising activity in preciinical tumor models. To date, phase I studies with aurora kinase inhibitors have shown that myelosuppression is the close-limiting toxicity, and disease stabilization was achieved in a number of tumor types, including non-smallcell lung cancer. Phase II trials are under way in selected tumor types. This article reviews the biology of aurora kirmes, their potential role in the treatment of lung cancer, and challenges in the dinical development of this unique dass of antineoplastic agents.

引用

页码：93 / 98

页数：6

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