Ferrofluids of magnetic multicore nanoparticles for biomedical applications

被引：138

作者：

Dutz, Silvio ^{[1
]}

Clement, Joachim H. ^{[2
]}

Eberbeck, Dietmar ^{[3
]}

Gelbrich, Thorsten ^{[4
]}

Hergt, Rudolf ^{[1
]}

Mueller, Robert ^{[1
]}

Wotschadlo, Jana ^{[2
]}

Zeisberger, Matthias ^{[1
]}

机构：

[1] Inst Photon Technol, D-07745 Jena, Germany

[2] Univ Clin Jena, Dept Internal Med 2, D-07740 Jena, Germany

[3] Phys Tech Bundesanstalt, D-10587 Berlin, Germany

[4] Univ Dusseldorf, Inst Organ Chem & Macromol Chem, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

关键词：

Cellular uptake; Fractionation; Hysteresis; Magnetic loss; Magnetic nanoparticle; Magnetite; Multicore particle; Specific heating power; IN-VITRO; LOSSES; CELLS;

D O I：

10.1016/j.jmmm.2009.02.073

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

For a variety of magnetically based biomedical applications, it is advantageous to use sedimentation stable suspensions of relatively large(d > 420 nm) magnetic core-shell nanoparticles. Water-based suspensions of multicore nanoparticles were prepared by coating of the particles (synthesized by means of a modified alkaline precipitation method) with a carboxymethyldextran shell. The resulting ferrofluids were structurally and magnetically characterized. It was found that these fluids show a specific heating power of about 60W/g (f = 400 kHz, H = 10kA/m). This value was increased upto 330W/g by a simple fractionation method based on centrifugation. Finally, the cellular uptake of the multicore nanoparticles was demonstrated. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：1501 / 1504

页数：4

共 22 条

[1] Polyaspartate coated magnetite nanoparticles for biomedical applications [J].