L-Nucleoside enantiomers as antivirals drugs:: A mini-review

被引：189

作者：

Mathe, Christophe ^{[1
]}

Gosselin, Gilles ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5625, Lab Chim Organ Biomol Synthese, F-34095 Montpellier, France

来源：

ANTIVIRAL RESEARCH | 2006年 / 71卷 / 2-3期

关键词：

L-nucleoside enantiomers; antiviral drugs;

D O I：

10.1016/j.antiviral.2006.04.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents (c) 2006 Elsevier B.V. All rights reserved.

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收藏

页码：276 / 281

页数：6

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