L-Nucleoside enantiomers as antivirals drugs:: A mini-review

被引：189

作者：

Mathe, Christophe ^{[1
]}

Gosselin, Gilles ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5625, Lab Chim Organ Biomol Synthese, F-34095 Montpellier, France

来源：

ANTIVIRAL RESEARCH | 2006年 / 71卷 / 2-3期

关键词：

L-nucleoside enantiomers; antiviral drugs;

D O I：

10.1016/j.antiviral.2006.04.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：276 / 281

页数：6

共 41 条

[11]

Furman P. A., 1995, International Antiviral News, V3, P74

[12] New malaria chemotherapy developed by utilization of a unique parasite transport system [J].

Gero, AM ;

Dunn, CG ;

Brown, DM ;

Pulenthiran, K ;

Gorovits, EL ;

Bakos, T ;

Weis, AL .

CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (11) :867-877

[13] Epstein-Barr virus infections: prospects for treatment [J].

Gershburg, E ;

Pagano, JS .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (02) :277-281

[14]

GOSSELIN G, 2004, FRONTIERS NUCLEOSIDE, P309

[15] Species differences in troxacitabine pharmacokinetics and pharmacodynamics: Implications for clinical development [J].

Gourdeau, H ;

Leblond, L ;

Hamelin, B ;

Dong, K ;

Ouellet, F ;

Boudreau, C ;

Custeau, D ;

Richard, A ;

Gilbert, MJ ;

Jolivet, J .

CLINICAL CANCER RESEARCH, 2004, 10 (22) :7692-7702

[16] CYTOMEGALO-VIRUS INFECTION IS ASSOCIATED WITH CARDIAC ALLOGRAFT-REJECTION AND ATHEROSCLEROSIS [J].

GRATTAN, MT ;

MORENOCABRAL, CE ;

STARNES, VA ;

OYER, PE ;

STINSON, EB ;

SHUMWAY, NE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 261 (24) :3561-3566

[17] L-nucleosides as chemotherapeutic agents [J].

Gumina, G ;

Song, GY ;

Chu, CK .

FEMS MICROBIOLOGY LETTERS, 2001, 202 (01) :9-15

[18]

Gumina Giuseppe, 2002, Current Topics in Medicinal Chemistry, V2, P1065, DOI 10.2174/1568026023393138

[19] Single- and multiple-dose pharmacokinetics of levovirin valinate hydrochloride (R1518) in healthy volunteers [J].

Huang, Y ;

Ostrowitzki, S ;

Hill, G ;

Navarro, M ;

Berger, N ;

Kopeck, P ;

Mau, CI ;

Alfredson, T ;

Lal, R .

JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 45 (05) :578-588

[20] Lamivudine - A review of its therapeutic potential in chronic hepatitis B [J].

Jarvis, B ;

Faulds, D .

DRUGS, 1999, 58 (01) :101-141

← 1 2 3 4 5 →