Anti-tumour necrosis factor-alpha therapy over conventional therapy improves endothelial function in adults with rheumatoid arthritis

被引:57
作者
Bilsborough, William
Keen, Helen
Taylor, Andrew
O'Driscoll, Gerard J.
Arnolda, Leonard
Green, Daniel J.
机构
[1] Royal Perth Hosp, Cardiac Transplant Unit, Perth, WA 6847, Australia
[2] Royal Perth Hosp, Dept Cardiothorac Surg, Perth, WA 6847, Australia
[3] Royal Perth Hosp, Dept Rheumatol, Perth, WA 6847, Australia
[4] Univ Western Australia, Sch Human Movement & Exercise Sci, Nedlands, WA 6009, Australia
关键词
endothelium; rheumatoid arthritis; infliximab; etanercept; ultrasound;
D O I
10.1007/s00296-006-0147-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rheumatoid arthritis (RA) is associated with cardiovascular morbidity and mortality and inflammation contributes to related endothelial dysfunction. We aimed to investigate the effect of anti-TNF alpha therapy on endothelial function in subjects with rheumatoid arthritis. We measured flow-mediated (FMD) and GTN-mediated dilation of the brachial artery before and following 36 weeks of anti-TNF alpha therapy in nine RA patients and in a group of RA patients on conventional therapy. Thirty-six weeks of anti-TNF alpha therapy improved FMD relative to those on conventional therapy (8.65 +/- 1.50 vs. 1.70 +/- 1.36%, P = 0.02). No significant changes in GTN responses were evident. Significant improvements in tender (P = 0.03) and swollen (P = 0.02) joint counts, patients' global self-assessment (P = 0.01) and DAS-28 scores (P = 0.04) were observed in the anti-TNF alpha treated group. The addition of anti-TNF alpha treatment to conventional therapy, in those with severe RA, reduces inflammatory symptoms and improves endothelial function, potentially lowering future atherosclerotic risk.
引用
收藏
页码:1125 / 1131
页数:7
相关论文
共 50 条
  • [1] Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction
    Al Suwaidi, J
    Hamasaki, S
    Higano, ST
    Nishimura, RA
    Holmes, DR
    Lerman, A
    [J]. CIRCULATION, 2000, 101 (09) : 948 - 954
  • [2] TUMOR-NECROSIS-FACTOR STIMULATES INTERLEUKIN-1 AND PROSTAGLANDIN-E2 PRODUCTION IN RESTING MACROPHAGES
    BACHWICH, PR
    CHENSUE, SW
    LARRICK, JW
    KUNKEL, SL
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 136 (01) : 94 - 101
  • [3] Bacon P. A., 2002, Autoimmunity Reviews, V1, P338, DOI 10.1016/S1568-9972(02)00100-3
  • [4] Bakland Gunnstein, 2003, Tidsskr Nor Laegeforen, V123, P2561
  • [5] Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
  • [6] Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis
    Bergholm, R
    Leirisalo-Repo, M
    Vehkavaara, S
    Mäkimattila, S
    Taskinen, MR
    Yki-Järvinen, H
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (10) : 1637 - 1641
  • [7] The role of nuclear factor-kappa B in cytokine gene regulation
    Blackwell, TS
    Christman, JW
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1997, 17 (01) : 3 - 9
  • [8] Charles P, 1999, J IMMUNOL, V163, P1521
  • [9] TRANSCRIPTIONAL REGULATION OF ENDOTHELIAL-CELL ADHESION MOLECULES - NF-KAPPA-B AND CYTOKINE-INDUCIBLE ENHANCERS
    COLLINS, T
    READ, MA
    NEISH, AS
    WHITLEY, MZ
    THANOS, D
    MANIATIS, T
    [J]. FASEB JOURNAL, 1995, 9 (10) : 899 - 909
  • [10] Biphasic regulation of NF-κB activity underlies the pro- and anti-inflammatory actions of nitric oxide
    Connelly, L
    Palacios-Callender, M
    Ameixa, C
    Moncada, S
    Hobbs, AJ
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (06) : 3873 - 3881