Anti-tumour necrosis factor-alpha therapy over conventional therapy improves endothelial function in adults with rheumatoid arthritis

被引:57
作者
Bilsborough, William
Keen, Helen
Taylor, Andrew
O'Driscoll, Gerard J.
Arnolda, Leonard
Green, Daniel J.
机构
[1] Royal Perth Hosp, Cardiac Transplant Unit, Perth, WA 6847, Australia
[2] Royal Perth Hosp, Dept Cardiothorac Surg, Perth, WA 6847, Australia
[3] Royal Perth Hosp, Dept Rheumatol, Perth, WA 6847, Australia
[4] Univ Western Australia, Sch Human Movement & Exercise Sci, Nedlands, WA 6009, Australia
关键词
endothelium; rheumatoid arthritis; infliximab; etanercept; ultrasound;
D O I
10.1007/s00296-006-0147-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rheumatoid arthritis (RA) is associated with cardiovascular morbidity and mortality and inflammation contributes to related endothelial dysfunction. We aimed to investigate the effect of anti-TNF alpha therapy on endothelial function in subjects with rheumatoid arthritis. We measured flow-mediated (FMD) and GTN-mediated dilation of the brachial artery before and following 36 weeks of anti-TNF alpha therapy in nine RA patients and in a group of RA patients on conventional therapy. Thirty-six weeks of anti-TNF alpha therapy improved FMD relative to those on conventional therapy (8.65 +/- 1.50 vs. 1.70 +/- 1.36%, P = 0.02). No significant changes in GTN responses were evident. Significant improvements in tender (P = 0.03) and swollen (P = 0.02) joint counts, patients' global self-assessment (P = 0.01) and DAS-28 scores (P = 0.04) were observed in the anti-TNF alpha treated group. The addition of anti-TNF alpha treatment to conventional therapy, in those with severe RA, reduces inflammatory symptoms and improves endothelial function, potentially lowering future atherosclerotic risk.
引用
收藏
页码:1125 / 1131
页数:7
相关论文
共 50 条
  • [41] Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    Venugopal, SK
    Devaraj, S
    Yuhanna, I
    Shaul, P
    Jialal, I
    [J]. CIRCULATION, 2002, 106 (12) : 1439 - 1441
  • [42] A self-fulfilling prophecy - C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Verma, S
    Wang, CH
    Li, SH
    Dumont, AS
    Fedak, PWM
    Badiwala, MV
    Dhillon, B
    Weisel, RD
    Li, RK
    Mickle, DAG
    Stewart, DJ
    [J]. CIRCULATION, 2002, 106 (08) : 913 - 919
  • [43] Endothelial function - A barometer for cardiovascular risk?
    Vita, JA
    Keaney, JF
    [J]. CIRCULATION, 2002, 106 (06) : 640 - 642
  • [44] CORONARY VASOMOTOR RESPONSE TO ACETYLCHOLINE RELATES TO RISK-FACTORS FOR CORONARY-ARTERY DISEASE
    VITA, JA
    TREASURE, CB
    NABEL, EG
    MCLENACHAN, JM
    FISH, RD
    YEUNG, AC
    VEKSHTEIN, VI
    SELWYN, AP
    GANZ, P
    [J]. CIRCULATION, 1990, 81 (02) : 491 - 497
  • [45] WallbergJonsson S, 1997, J RHEUMATOL, V24, P445
  • [46] Improved analysis of brachial artery ultrasound using a novel edge-detection software system
    Woodman, RJ
    Playford, DA
    Watts, GF
    Cheetham, C
    Reed, C
    Taylor, RR
    Puddey, IB
    Beilin, LJ
    Burke, V
    Mori, TA
    Green, D
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (02) : 929 - 937
  • [47] Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
    Xia, Y
    Zweier, JL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) : 6954 - 6958
  • [48] Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis
    Yki-Järvinen, H
    Bergholm, R
    Leirisalo-Repo, M
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2003, 62 (07) : 630 - 634
  • [49] TUMOR-NECROSIS-FACTOR DOWN-REGULATES AN ENDOTHELIAL NITRIC-OXIDE SYNTHASE MESSENGER-RNA BY SHORTENING ITS HALF-LIFE
    YOSHIZUMI, M
    PERRELLA, MA
    BURNETT, JC
    LEE, ME
    [J]. CIRCULATION RESEARCH, 1993, 73 (01) : 205 - 209
  • [50] MODULATION OF CORONARY VASOMOTOR TONE IN HUMANS - PROGRESSIVE ENDOTHELIAL DYSFUNCTION WITH DIFFERENT EARLY STAGES OF CORONARY ATHEROSCLEROSIS
    ZEIHER, AM
    DREXLER, H
    WOLLSCHLAGER, H
    JUST, H
    [J]. CIRCULATION, 1991, 83 (02) : 391 - 401