The pathogenesis and basis for treatment in multiple sclerosis

被引：19

作者：

Compston, A ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 2QQ, England

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2004年 / 106卷 / 03期

关键词：

multiple sclerosis; axonal injury; demyelination; remyelination; pathogenesis; immunology;

D O I：

10.1016/j.clineuro.2004.02.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The central concept underlying ideas on the pathogenesis of multiple sclerosis is that inflammatory events cause acute injury of axons and myelin. The phases of symptom onset, recovery, persistence and progression in multiple sclerosis can be summarized as functional impairment with intact structure due to direct effects of inflammatory mediators, demyelination and axonal injury with recovery through plasticity and remyelination, and chronic axonal loss due to failure of enduring remyelination from loss of trophic support for axons normally provided by cells of the oligodendrocyte lineage. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：246 / 248

页数：3

共 19 条

[11] Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis [J].

Pluchino, S ;

Quattrini, A ;

Brambilla, E ;

Gritti, A ;

Salani, G ;

Dina, G ;

Galli, R ;

Del Carro, U ;

Amadio, S ;

Bergami, A ;

Furlan, R ;

Comi, G ;

Vescovi, AL ;

Martino, G .

NATURE, 2003, 422 (6933) :688-694

[12] Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible [J].

Redford, EJ ;

Kapoor, R ;

Smith, KJ .

BRAIN, 1997, 120 :2149-2157

[13] Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis [J].

Scolding, N ;

Franklin, R ;

Stevens, S ;

Heldin, CH ;

Compston, A ;

Newcombe, J .

BRAIN, 1998, 121 :2221-2228

[14]

Smith KJ, 2001, ANN NEUROL, V49, P470

[15] Axonal transection in the lesions of multiple sclerosis [J].

Trapp, BD ;

Peterson, J ;

Ransohoff, RM ;

Rudick, R ;

Mörk, S ;

Bö, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (05) :278-285

[16] A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons [J].

Wilkins, A ;

Chandran, S ;

Compston, A .

GLIA, 2001, 36 (01) :48-57

[17] Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: A novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor [J].

Wilkins, A ;

Majed, H ;

Layfield, R ;

Compston, A ;

Chandran, S .

JOURNAL OF NEUROSCIENCE, 2003, 23 (12) :4967-4974

[18] Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord [J].

Wolswijk, G .

BRAIN, 2002, 125 :338-349

[19]

ZAJICEK JP, 1992, BRAIN, V115, P1611, DOI 10.1093/brain/115.6.1611-a

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