Towards novel processes for the fine-chemical and pharmaceutical industries

被引:55
作者
Huisman, GW [1 ]
Gray, D [1 ]
机构
[1] Codexis Inc, Redwood City, CA 94063 USA
关键词
D O I
10.1016/S0958-1669(02)00335-X
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In response to the need in the pharmaceutical industry for more complex, chiral molecules, fine-chemical companies are embracing new manufacturing technologies to produce compounds of these specifications. In particular, recent developments in biocatalysis combined with novel process engineering are providing improved methods for the production of valuable chemical intermediates.
引用
收藏
页码:352 / 358
页数:7
相关论文
共 38 条
[1]   A P450BM-3 mutant hydroxylates alkanes, cycloalkanes, arenes and heteroarenes [J].
Appel, D ;
Lutz-Wahl, S ;
Fischer, P ;
Schwaneberg, U ;
Schmid, RD .
JOURNAL OF BIOTECHNOLOGY, 2001, 88 (02) :167-171
[2]   Glutamate synthesis via photoreduction of NADP+ by photostable chlorophyllide coupled with polyethylene-glycol [J].
Asada, H ;
Itoh, T ;
Kodera, Y ;
Matsushima, A ;
Hiroto, M ;
Nishimura, H ;
Inada, Y .
BIOTECHNOLOGY AND BIOENGINEERING, 2001, 76 (01) :86-90
[3]   Lessons from metabolic engineering for functional genomics and drug discovery [J].
Bailey, JE .
NATURE BIOTECHNOLOGY, 1999, 17 (07) :616-618
[4]  
BERRY A, 2001, Patent No. 0004182
[5]   The search for the ideal biocatalyst [J].
Burton, SG ;
Cowan, DA ;
Woodley, JM .
NATURE BIOTECHNOLOGY, 2002, 20 (01) :37-45
[6]   Directed evolution of a fungal peroxidase [J].
Cherry, JR ;
Lamsa, MH ;
Schneider, P ;
Vind, J ;
Svendsen, A ;
Jones, A ;
Pedersen, AH .
NATURE BIOTECHNOLOGY, 1999, 17 (04) :379-384
[7]   Lipase/palladium-catalyzed asymmetric transformations of ketoximes to optically active amines [J].
Choi, YK ;
Kim, MJ ;
Ahn, Y ;
Kim, MJ .
ORGANIC LETTERS, 2001, 3 (25) :4099-4101
[8]   Dynamic kinetic resolution of acyclic allylic acetates using lipase and palladium [J].
Choi, YK ;
Suh, JH ;
Lee, D ;
Lim, IT ;
Jung, JY ;
Kim, MJ .
JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (22) :8423-8424
[9]  
Fischer E., 1894, Chem. Gesellschaft, V27, P2985, DOI DOI 10.1002/CBER.18940270364
[10]   Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars [J].
Fong, S ;
Machajewski, TD ;
Mak, CC ;
Wong, CH .
CHEMISTRY & BIOLOGY, 2000, 7 (11) :873-883