Stereoselective synthesis of (+)-boronolide

被引：47

作者：

Carda, M ^{[1
]}

Rodríguez, S

Segovia, B

Marco, JA

机构：

[1] Univ Jaume 1, UP Quim Inorgan & Organ, E-12080 Castellon de La Plana, Spain

[2] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 18期

关键词：

D O I：

10.1021/jo025813f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The delta-lactone boronolide (+)-1, a pharmacologically active, naturally occurring product, has been synthesized in enantiopure form with L-erythrulose as the chiral starting material. The key steps of the synthesis were a highly stereoselective aldol-reduction one-pot sequence, an indium-mediated diastereoselective aldehyde allylation, and a ring-closing metathesis.

引用

页码：6560 / 6563

页数：4

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