Do beta-adrenoceptors and serotonin 5-HT1A receptors have similar functions in the control of intraocular pressure in the rabbit?

被引：21

作者：

Osborne, NN

Chidlow, G

机构：

[1] Nuffield Laboratory of Ophthalmology, University of Oxford

来源：

OPHTHALMOLOGICA | 1996年 / 210卷 / 05期

基金：

英国惠康基金;

关键词：

serotonin; beta-blockers; intraocular pressure; 5-HT1A receptors;

D O I：

10.1159/000310730

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Serotonin 5-HT1A-type and beta-adrenergic receptors have similar molecular characteristics, which explains why certain substances like propranolol have affinities for both receptor types. Activation of 5-HT1A receptors leads to a decrease in intracellular cAMP levels whereas the opposite occurs for beta-adrenergic receptors. Both 5-HT1A and beta-adrenergic receptors exist in the rabbit ciliary processes. Topical application of the 5-HT1A agonist, 8-hydroxydipropylaminotetralin (8-OH-DPAT) reduces intraocular pressure (IOP). beta-Antagonists are also known to reduce IOP. It is postulated that substances which have an affinity for 5-HT1A and/or beta-adrenergic receptors and lead to a reduction in intracellular cAMP levels in the ciliary processes diminish IOP.

引用

收藏

页码：308 / 314

页数：7

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