1,7-asymmetric induction in a nitrogen ring expansion process facilitated by in situ tethering

被引：27

作者：

Furness, K ^{[1
]}

Aubé, J ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 03期

关键词：

D O I：

10.1021/ol990685b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] There are only a few methods for the asymmetric ring expansion of prochiral ketones. Symmetrically substituted cyclohexanones can be converted to the corresponding ring expanded caprolactam with excellent 1,7 diastereoselectivity (greater than or equal to 93% ds) and yields (greater than or equal to 86%), using a chiral hydroxy azide-mediated Schmidt reaction.

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收藏

页码：495 / 497

页数：3

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