Total synthesis of dehydroaltenusin

被引：59

作者：

Kamisuki, S

Takahashi, S ^{[1
]}

Mizushina, Y

Hanashima, S

Kuramochi, K

Kobayashi, S

Sakaguchi, K

Nakata, T

Sugawara, F

机构：

[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[2] Sci Univ Tokyo, Dept Appl Biol Sci, Noda, Chiba 2788510, Japan

[3] Kobe Gakuin Univ, Dept Nutrit Sci, Kobe, Hyogo 6512180, Japan

[4] Sci Univ Tokyo, Genome & Drug Discovery Res Ctr, Chiba 2788510, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 27期

基金：

日本学术振兴会;

关键词：

dehydroaltenusin; DNA polymerase alpha; enzyme inhibitor;

D O I：

10.1016/j.tet.2004.05.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described. The key step involves Suzuki-coupling reaction of an aryl triflate prepared from 2,4,6-trihydroxybenzoic acid with a catechol-derived boronic acid or boronic ester. The synthetic product was evaluated as a potent inhibitor against eukaryotic DNA polymerase a and other DNA polymerases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5695 / 5700

页数：6

共 24 条

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[Anonymous], 1990, NATURE

[2] THE METABOLITES OF TALAROMYCES-FLAVUS .1. METABOLITES OF THE ORGANIC EXTRACTS [J].