Antiviral therapy for adenovirus infections

被引：81

作者：

Lenaerts, L. ^{[1
]}

Naesens, L. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

ANTIVIRAL RESEARCH | 2006年 / 71卷 / 2-3期

关键词：

adenovirus; immunocompromised host; antiviral; cidofovir; ribavirin; immunotherapy;

D O I：

10.1016/j.antiviral.2006.04.007

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The treatment of severe adenovirus keratoconjunctivitis and life-threatening adenovirus infections in immurrocompromised patients is still unsatisfactory. We here review the mode of action and antiviral data for cidofovir and ribavirin, obtained in cell culture, animal models or patients. Several nucleoside or nucleotide analogues have been described that target the adenovirus polymerase, whereas other antiviral targets have been poorly investigated. Furthermore, optimal therapeutic response may be achieved by combining antiviral therapy with immunotherapeutic approaches, as currently being explored. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：172 / 180

页数：9

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