Fusion of autoradiographs with an MR volume using 2-D and 3-D linear transformations

被引:88
作者
Malandain, G
Bardinet, E
Nelissen, K
Vanduffel, W
机构
[1] INRIA, Epidaure Team, F-06902 Sophia Antipolis, France
[2] CNRS, UPR 640, LENA, F-75651 Paris 13, France
[3] Katholieke Univ Leuven, Neuro & Psychofysiol Lab, B-3000 Louvain, Belgium
[4] MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Charlestown, MA 02129 USA
关键词
histology; autoradiography; mortem;
D O I
10.1016/j.neuroimage.2004.04.038
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the past years, the development of 3-D medical imaging has enabled the 3-D imaging of in vivo tissues, from an anatomical (MR, CT) or even functional (fMRI, PET, SPECT) point of view. However, despite immense technological progress, the resolution of these images is still short of the level of anatomical or functional details that in vitro imaging (e.g., histology, autoradiography) permits. The motivation of this work is to compare fMRI activations to activations observed in autoradiographic images from the same animals. We aim to fuse post-mortem autoradiographic data with a pre-mortem anatomical MR image. We first reconstruct a 3-D volume from the 2-D autoradiographic sections, coherent both in geometry and intensity. Then, this volume is fused with the MR image. This way, we ensure that the reconstructed 3-D volume can be superimposed onto the MR image that represents the reference anatomy. We demonstrate that this fusion can be achieved by using only simple global transformations (rigid and/or affine, 2-D and 3-D), while yielding very satisfactory results. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:111 / 127
页数:17
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