Immunochemical faecal occult blood test: number of samples and positivity cutoff. What is the best strategy for colorectal cancer screening?

被引：85

作者：

Grazzini, G. ^{[1
]}

Visioli, C. B. ^{[1
]}

Zorzi, M. ^{[2
]}

Ciatto, S. ^{[1
]}

Banovich, F. ^{[3
]}

Bonanomi, A. G. ^{[1
]}

Bortoli, A. ^{[4
]}

Castiglione, G. ^{[1
]}

Cazzola, L. ^{[5
]}

Confortini, M. ^{[1
]}

Mantellini, P. ^{[1
]}

Rubeca, T. ^{[1
]}

Zappa, M. ^{[1
]}

机构：

[1] ISPO Canc Prevent & Res Inst Florence, Dept Screening, I-50131 Florence, Italy

[2] Ist Oncol Veneto, Venetian Tumour Registry, I-35128 Padua, Italy

[3] Local Hlth Unit 4, I-36016 Thiene, Italy

[4] Local Hlth Unit 22, I-37012 Bussolengo, Italy

[5] Local Hlth Unit 2, I-32032 Feltre, Italy

来源：

BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 02期

关键词：

immunochemical test; colorectal neoplasms; faecal occult blood test; screening; cutoff;

D O I：

10.1038/sj.bjc.6604864

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunochemical faecal occult blood tests have shown a greater sensitivity than guaiac test in colorectal cancer screening, but optimal number of samples and cutoff have still to be defined. The aim of this multicentric study was to evaluate the performance of immunochemical-based screening strategies according to different positivity thresholds (80, 100, 120 ng ml(-1)) and single vs double sampling (one, at least one, or both positive samples) using 1-day sample with cutoff at 100 ng ml(-1) as the reference strategy. A total of 20596 subjects aged 50-69 years were enrolled from Italian population-based screening programmes. Positivity rate was 4.5% for reference strategy and 8.0 and 2.0% for the most sensitive and the most specific strategy, respectively. Cancer detection rate of reference strategy was 2.8 parts per thousand, and ranged between 2.1 and 3.4 parts per thousand in other strategies; reference strategy detected 15.6 parts per thousand advanced adenomas (range 10.0 22.5 parts per thousand). The number needed to scope to find a cancer or an advanced adenoma was lower than 2 (1.5-1.7) for the most specific strategies, whereas it was 2.4-2.7, according to different thresholds, for the most sensitive ones. Different strategies seem to have a greater impact on adenomas rather than on cancer detection rate. The study provides information when deciding screening protocols and to adapt them to local resources.

引用

页码：259 / 265

页数：7

共 24 条

[21] Performance characteristics and evaluation of an automated-developed and quantitative, immunochemical, fecal occult blood screening test [J].

Vilkin, A ;

Rozen, P ;

Levi, Z ;

Waked, A ;

Maoz, E ;

Birkenfeld, S ;

Niv, Y .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (11) :2519-2525

[22]

Zappa M, 2001, INT J CANCER, V92, P151, DOI 10.1002/1097-0215(200102)9999:9999<::AID-IJC1149>3.3.CO

[23]

2-Y

[24]

Zorzi M, 2009, EPIDEMIOL PREV, V33, P57

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