Case report:: Kinetics of Epstein-Barr virus load in a bone marrow transplant patient with no sign of lymphoproliferative disease

被引：18

作者：

Biasolo, MA

Calistri, A

Cesaro, S

Gentile, G

Mengoli, C

Palù, G

机构：

[1] Univ Padua, Dipartimento Istol Microbiol & Biotecnol Med, Padua, Italy

[2] Univ Padua, Clin Oncoematol Pediat, Padua, Italy

[3] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Rome, Italy

来源：

JOURNAL OF MEDICAL VIROLOGY | 2003年 / 69卷 / 02期

关键词：

EBV load growth rate; post-transplant lymphoproliferation;

D O I：

10.1002/jmv.10285

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The kinetics of Epstein-Barr virus (EBV) load was measured in peripheral blood mononuclear cells of a severely immunocompromised allogeneic bone marrow recipient child, in conditions not associated with lymphoproliferative disease. The viral doubling time was 46.4 hr. The study permitted monitoring EBV clearance from blood, when the anti-rejection therapy was interrupted. Likely, this is the first accurate kinetic assessment of EBV load increasing phase in a clinical context marked by the absence of an overt post-transplant lymphoproliferative disease. According to these data gamma-herpesviruses behave like beta-herpesviruses in being capable of rapid growth.

引用

页码：220 / 224

页数：5

共 12 条

[11] Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients [J].