Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target

被引：562

作者：

Golia, Enrica ^{[1
]}

Limongelli, Giuseppe ^{[1
]}

Natale, Francesco ^{[1
]}

Fimiani, Fabio ^{[1
]}

Maddaloni, Valeria ^{[1
]}

Pariggiano, Ivana ^{[1
]}

Bianchi, Renatomaria ^{[1
]}

Crisci, Mario ^{[1
]}

D'Acierno, Ludovica ^{[1
]}

Giordano, Roberto ^{[1
]}

Di Palma, Gaetano ^{[1
]}

Conte, Marianna ^{[1
]}

Golino, Paolo ^{[2
]}

Russo, Maria Giovanna ^{[1
]}

Calabro, Raffaele ^{[1
]}

Calabro, Paolo ^{[1
]}

机构：

[1] Univ Naples 2, Cardiothorac & Resp Sci Dept, Div Cardiol, AO Dei Colli Monaldi Hosp, I-80131 Naples, Italy

[2] Univ Naples 2, AO S Anna & S Sebastiano, Cardiothorac & Resp Sci Dept, Div Cardiol, Caserta, Italy

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2014年 / 16卷 / 09期

关键词：

Atherosclerosis; Inflammation; Statins; inflammasome; IL-1; beta; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; INTERLEUKIN-1-BETA INHIBITION; NATURAL-HISTORY; STATIN THERAPY; TISSUE FACTOR; ATHEROSCLEROSIS; PREVENTION; ATHEROGENESIS; PRAVASTATIN;

D O I：

10.1007/s11883-014-0435-z

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

Atherosclerosis represents the most common pathological substrate of coronary heart disease (CHD), and the characterization of the disease as a chronic low-grade inflammatory condition is now largely accepted. A number of mediators of inflammation have been widely studied, both as surrogate biomarkers and as causal agents, in the pathophysiological network of atherogenesis and plaque vulnerability. The epidemiological observation that biomarkers of inflammation are associated with clinical cardiovascular risk supports the theory that targeted anti-inflammatory treatment appears to be a promising strategy in reducing residual cardiovascular risk on the background of traditional medical therapy. A large number of randomized controlled trials have shown that drugs commonly used in cardiovascular disease (CVD), such as statins, may be effective in the primary and secondary prevention of cardiovascular events through an anti-inflammatory effect. Moreover, several anti-inflammatory drugs are being tested for their potential to reduce residual cardiovascular risk on the background of validated medical therapy for atherosclerotic disease. In this paper, we review relevant evidence with regard to the relationship between inflammation and CVD, from pathogenesis to therapeutic strategies.

引用

页数：7

共 52 条

[1]

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation [J].