Expression of growth hormone receptor in the human brain

被引：29

作者：

Castro, JR

Costoya, JA

Gallego, R

Prieto, A

Arce, VM

Señarís, R

机构：

[1] Fac Med, Dept Fisiol, Santiago De Compostela 15705, Spain

[2] Univ Santiago De Compostela, Dept Ciencias Morfol, Santiago De Compostela, Spain

[3] Hosp Xeral De Galicia, Serv Neurociruxia, Santiago De Compostela, Spain

来源：

NEUROSCIENCE LETTERS | 2000年 / 281卷 / 2-3期

关键词：

growth hormone; growth hormone receptor; human brain;

D O I：

10.1016/S0304-3940(00)00830-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study was designed to investigate the presence of growth hormone receptor (GHR) expression in the human brain tissue, both normal and tumoral, as well as in the human glioblastoma cell line U87MG. Reverse transcription-polymerase chain:reaction revealed the presence of GHR mRNA in all brain samples investigated and in U87MG cells. GHR immunoreactivity was also detected in this cell line using both immunocytochemistry and western blotting, All together, our data demonstrate the existence of GHR expression within the central nervous system (CNS), thus supporting a possible role for GH in the CNS physiology. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

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页码：147 / 150

页数：4

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