Amygdala Inhibitory Circuits and the Control of Fear Memory

被引：709

作者：

Ehrlich, Ingrid ^{[1
]}

Humeau, Yann ^{[2
,3
]}

Grenier, Francois ^{[1
]}

Ciocchi, Stephane ^{[1
]}

Herry, Cyril ^{[1
]}

Luthi, Andreas ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

[2] Univ Strasbourg, Inst Neurosci Cellulaires & Integrat, F-67084 Strasbourg, France

[3] CNRS, UMR7168, F-67084 Strasbourg, France

来源：

NEURON | 2009年 / 62卷 / 06期

基金：

奥地利科学基金会; 瑞士国家科学基金会;

关键词：

RAT BASOLATERAL AMYGDALA; LONG-TERM POTENTIATION; BIDIRECTIONAL SYNAPTIC PLASTICITY; CENTRAL EXTENDED AMYGDALA; PARVALBUMIN-IMMUNOREACTIVE INTERNEURONS; LATERAL AMYGDALA; CONDITIONED FEAR; CENTRAL NUCLEUS; PREFRONTAL CORTEX; NMDA RECEPTORS;

D O I：

10.1016/j.neuron.2009.05.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Classical fear conditioning is a powerful behavioral paradigm that is widely used to study the neuronal substrates of learning and memory. Previous studies have clearly identified the amygdala as a key brain structure for acquisition and storage of fear memory traces. Whereas the majority of this work has focused on principal cells and glutamatergic transmission and its plasticity, recent studies have started to shed light on the intricate roles of local inhibitory circuits. Here, we review current understanding and emerging concepts of how local inhibitory circuits in the amygdala control the acquisition, expression, and extinction of conditioned fear at different levels.

引用

页码：757 / 771

页数：15

共 198 条

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