Scleroglucan/borax/drug hydrogels: Structure characterisation by means of rheological and diffusion experiments

被引：32

作者：

Grassi, Mario ^{[1
]}

Lapasin, Romano ^{[1
]}

Coviello, Tommasina ^{[2
]}

Matricardi, Pietro ^{[2
]}

Di Meo, Chiara ^{[2
]}

Alhaique, Franco ^{[2
]}

机构：

[1] Univ Trieste, Dipartimento Ingn Chim Ambiente & Mat Prime, I-34127 Trieste, Italy

[2] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, I-00185 Rome, Italy

来源：

CARBOHYDRATE POLYMERS | 2009年 / 78卷 / 03期

关键词：

Scleroglucan-borax; Rheology; Drug release; Mesh size; Equivalent network; Free volume theory; SCHIZOPHYLLUM-COMMUNE POLYSACCHARIDE; TRIPLE-HELIX; DILUTE-SOLUTION; LIGHT-SCATTERING; DRUG-DELIVERY; BEHAVIOR; DEGRADATION; MIXTURES; WATER;

D O I：

10.1016/j.carbpol.2009.04.025

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

This paper is aimed to the macro- and microscopic characterisation of a scleroglucan-borax gel system eventually hosting model drugs. A theological study was carried out, also as a function of temperature, on samples at different polymer concentrations in the presence and without guest model drug. Applying the generalised Maxwell model the mechanical spectra, showing the gel-like characteristics dependent on polymer concentration. were obtained. Flory's theory and the equivalent network approach were applied to the theological data in order to describe the molecular arrangement of the scleroglucan chains in the presence of borate ions with an estimation of the network mesh size, xi. Diffusion experiments of three model drugs, with different van der Waals radius, allowed the determination of the diffusion coefficients. An evaluation of the network mesh size was also obtained by means of a modified free Volume theory and a good agreement between the two sets of xi values was found. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：377 / 383

页数：7

共 36 条

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A POSSIBLE PH-CONTROLLED DRUG DELIVERY SYSTEM BASED ON A DERIVATIVE OF THE POLYSACCHARIDE SCLEROGLUCAN [J].