Prospective determination of plasma imipenem concentrations in critically ill children

被引：26

作者：

Giannoni, Eric

Moreillon, Philippe

Cotting, Jacques

Moessinger, Adrien

Bille, Jacques

Decosterd, Laurent

Zanetti, Giorgio

Majcherczyk, Paul

Bugnon, Denis

机构：

[1] Univ Lausanne, Inst Fundamental Microbiol, Dept Fundamental Microbiol, CH-1015 Lausanne, Switzerland

[2] CHU Vaudois, Dept Pediat, CH-1011 Lausanne, Switzerland

[3] CHU Vaudois, Inst Microbiol, CH-1011 Lausanne, Switzerland

[4] CHU Vaudois, Div Clin Pharmacol, CH-1011 Lausanne, Switzerland

[5] CHU Vaudois, Dept Hosp Hyg, CH-1011 Lausanne, Switzerland

[6] Sch Med, UPRES EA 1156, Lab Antibiol, F-44035 Nantes 01, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 07期

关键词：

D O I：

10.1128/AAC.01149-05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4X at peak and > 10X at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.

引用

页码：2563 / 2568

页数：6

共 25 条

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