Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles

被引：57

作者：

Evans, TM

Gardiner, JM

Mahmood, N

Smis, M

机构：

[1] UNIV MANCHESTER, INST SCI & TECHNOL, DEPT CHEM, MANCHESTER M60 1QD, LANCS, ENGLAND

[2] MRC, CTR COLLABORAT, LONDON NW7 1AD, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(97)00022-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC(50) of 0.5 mu M. There is a correlation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Replacing vinyl by the 2,2-dimethyl vinyl group increases antiviral selectivity. (C) 1997, Elsevier Science Ltd.

引用

页码：409 / 412

页数：4

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